Histopathology of drug rash with eosinophilia and systemic symptoms syndrome: a morphological and phenotypical study
| Autor: | Pierre Wolkenstein, Laurence Valeyrie-Allanore, Marie-Hélène Delfau-Larue, Nicolas Ortonne, S. de Feraudy, J.-C. Roujeau, Sylvie Bastuji-Garin, Olivier Chosidow, Janine Wechsler, Tu Anh Duong |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Erythema Adolescent Allopurinol T-Lymphocytes Erythroderma Minocycline Dermatology Gout Suppressants Young Adult Biopsy Trimethoprim Sulfamethoxazole Drug Combination Maculopapular rash medicine Eosinophilia Humans Aged Retrospective Studies Aged 80 and over B-Lymphocytes Atypical Lymphocyte integumentary system medicine.diagnostic_test business.industry Exanthema Middle Aged medicine.disease Immunohistochemistry Anti-Bacterial Agents Granzyme B Sulfasalazine Carbamazepine Phenotype Drug Hypersensitivity Syndrome Histopathology Female medicine.symptom business |
| Zdroj: | The British journal of dermatology. 173(1) |
| ISSN: | 1365-2133 |
| Popis: | SummaryBackground The histopathological features of drug rash with eosinophilia and systemic symptoms (DRESS) syndrome remain poorly characterized. Objectives To better characterize the histopathological features of DRESS syndrome, and define the phenotype of the effector cells in the skin and compare it with maculopapular rash (MPR). Methods We conducted a retrospective study on 50 skin biopsies from patients with DRESS syndrome (n = 36). Histopathological and immunophenotypical features were studied and compared with a series of MPRs (n = 20). Results Foci of interface dermatitis, involving cutaneous adnexae, were frequently seen in cases of DRESS. Eosinophils were seen in only 20% of cases and neutrophils in 42%. Eczematous (40%), interface dermatitis (74%), acute generalized exanthematic pustulosis-like (20%) and erythema multiforme-like (24%) patterns were observed. The association of two or three of these patterns in a single biopsy was significantly more frequent in cases of DRESS than in a series of nondrug-induced dermatoses (P |
| Databáze: | OpenAIRE |
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