High Heterogeneity of Echoviruses in Brazilian Children with Acute Gastroenteritis
| Autor: | Rafael Brustulin, Mayara Bertanhe, Geovani de Oliveira Ribeiro, Vanessa dos Santos Morais, Élcio Leal, Eric Delwart, Roberta Marcatti, Antonio Charlys da Costa, Adriana Luchs, Flavio Augusto de Pádua Milagres, Steven S. Witkin, Endrya do Socorro Fôro Ramos, Emerson Luiz Lima Araújo, Ulisses Alves Rosa, Fabiola Villanova |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Echovirus Genotype viruses 030106 microbiology lcsh:QR1-502 Genome Viral Biology medicine.disease_cause lcsh:Microbiology Article 03 medical and health sciences Feces pediatric virome Virology medicine Humans acute gastroenteritis gut virome Phylogeny Genetic diversity Phylogenetic tree Whole Genome Sequencing echovirus E enterovirus Aseptic meningitis Genetic Variation High-Throughput Nucleotide Sequencing Infant Sequence Analysis DNA Acute gastroenteritis medicine.disease Enterovirus B Human Gastroenteritis 030104 developmental biology Infectious Diseases Cross-Sectional Studies Child Preschool Acute Disease Epidemiological Monitoring Enterovirus RNA Viral Female Brazil |
| Zdroj: | Viruses Volume 13 Issue 4 Viruses, Vol 13, Iss 595, p 595 (2021) |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v13040595 |
| Popis: | Echoviruses (E) are a diverse group of viruses responsible for various pathological conditions in humans including aseptic meningitis, myocarditis, and acute flaccid paralysis. The detection and identification of echovirus genotypes in clinical samples is challenging due to its high genetic diversity. Here, we report the complete genome sequences of nine echoviruses, obtained by next-generation sequencing of 238 fecal samples from individuals with gastroenteritis in regions of Brazil. Detected viruses were classified into six genotypes: Three E1 sequences (BRA/TO-028, BRA/TO-069 and BRA/TO-236), one E3 (BRA/TO-018), one E11 (BRA/TO-086), one E20 (BRA/TO-016), two E29 (BRA/TO-030 and BRA/TO-193), and one E30 sequence (BRA/TO-032). Phylogenetic analysis indicated that the echoviruses E1 and E29 circulating in Brazil are divergent from strains circulating worldwide. The genotype diversity identified in our study may under-represent the total echovirus diversity in Brazil because of the small sample size and the restricted geographical distribution covered by the survey. |
| Databáze: | OpenAIRE |
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