IMMUNOLOGICAL DISTURBANCES IN TOXIC MULTINODULAR GOITRE AND ACTIVE GRAVES’DISEASE
| Autor: | M. T. Rezkallah-Iwasso, M. T. S. Peraçoli, Y. Kiy, N. G. S. Mota |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Rosette Formation endocrine system diseases Endocrinology Diabetes and Metabolism Graves' disease Immunoglobulins Endocrinology Antigen Microsomes Internal medicine Leukocytes medicine Humans Toxic multinodular goitre Aged Phytohaemagglutinin Immunity Cellular biology business.industry Thyroid Middle Aged medicine.disease Graves Disease medicine.drug_formulation_ingredient medicine.anatomical_structure Antibody Formation Cell Migration Inhibition Humoral immunity Immunology biology.protein Female Antibody business Thyroid extract Goiter Nodular |
| Zdroj: | Clinical Endocrinology. 16:11-17 |
| ISSN: | 1365-2265 0300-0664 |
| DOI: | 10.1111/j.1365-2265.1982.tb03142.x |
| Popis: | SUMMARY Cell-mediated and humoral immunity were studied in seventeen patients with toxic multinodular goitre, ten with active Graves’disease and fourteen healthy controls. The study included determination of sheep erythrocyte and complement rosette-forming cells in the peripheral blood, immunoglobulin levels, titres of microsomal antibodies and migration inhibition test using thyroid extract and phytohaemagglutinin. When compared with controls the patients showed a positive response to thyroid antigen in the leucocyte migration inhibition test. Microsomal antibodies were detected in seven out of ten active Graves’disease patients against two out of seventeen of those with toxic multinodular goitre. Significantly increased IgG and IgA and decreased IgM levels were found only in the toxic multinodular group. These data provide further evidence for immunological disturbances in toxic multinodular goitre. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text