| Autor: |
Andrew H. Karaba, Jake D. Kim, Teresa P-Y Chiang, Jennifer L. Alejo, Aura T. Abedon, Jonathan Mitchell, Amy Chang, Yolanda Eby, Trevor Scott Johnston, Tihitina Aytenfisu, Casey Hussey, Alexa Jefferis, Nicole Fortune, Rivka Abedon, Letitia Thomas, Daniel S. Warren, Ioannis Sitaras, Andrew Pekosz, Robin K. Avery, Allan B. Massie, William A. Clarke, Aaron A.R. Tobian, Dorry L. Segev, William A. Werbel |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
medRxiv |
| Popis: |
Neutralizing antibody responses are attenuated in many solid organ transplant recipients (SOTRs) despite SARS-CoV-2 vaccination. Pre-exposure prophylaxis (PrEP) with the monoclonal antibody combination Tixagevimab and Cilgavimab (T+C) might augment immunoprotection, yet activity against Omicron sublineages in vaccinated SOTRs is unknown. Vaccinated SOTRs who received 300+300mg T+C (either single dose or two 150+150mg doses) within a prospective observational cohort submitted pre- and post-injection samples between 1/10/2022-4/4/2022. Binding antibody (anti-receptor binding domain [RBD], Roche) and surrogate neutralization (%ACE2 inhibition; ≥20% connoting neutralizing inhibition, Meso Scale Discovery) were measured against variants including Omicron sublineages BA.1 and BA.2. Data were analyzed using the Wilcoxon matched-pairs signed-rank test and McNemar’s test. Among 61 participants, median (IQR) anti-RBD increased from 424 (IQR |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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