Oral administration of Aloe vera gel powder prevents UVB-induced decrease in skin elasticity via suppression of overexpression of MMPs in hairless mice
| Autor: | Fumiaki Abe, Miyuki Tanaka, Ruiquing Yao, Yuki Yamamoto, Kouji Yamauchi, Eriko Misawa, Kazumi Nabeshima, Marie Saito, Fukumi Furukawa |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Administration Oral Pharmacology Matrix metalloproteinase Applied Microbiology and Biotechnology Biochemistry Analytical Chemistry Skin Aging Extracellular matrix 030207 dermatology & venereal diseases chemistry.chemical_compound Mice 0302 clinical medicine Oral administration Hyaluronic acid Gene expression Glucuronosyltransferase Hyaluronic Acid skin and connective tissue diseases Skin biology integumentary system Chemistry General Medicine Extracellular Matrix Matrix Metalloproteinase 9 Matrix Metalloproteinase 2 Female Adiponectin Powders Biotechnology Ultraviolet Rays Aloe vera 03 medical and health sciences Matrix Metalloproteinase 13 Animals Aloe Molecular Biology Mice Hairless Plant Extracts Organic Chemistry biology.organism_classification Elasticity Hairless 030104 developmental biology Gene Expression Regulation Immunology Gels Hyaluronan Synthases |
| Zdroj: | Bioscience, biotechnology, and biochemistry. 80(7) |
| ISSN: | 1347-6947 |
| Popis: | This study reports the effects of oral Aloe vera gel powder (AVGP) containing Aloe sterols on skin elasticity and the extracellular matrix in ultraviolet B (UVB)-irradiated hairless mice. Ten-week-old hairless mice were fed diets containing 0.3% AVGP for 8 weeks and irradiated UVB for 6 weeks. Mice treated with AVGP showed significant prevention of the UVB-induced decrease in skin elasticity. To investigate the mechanism underlying this suppression of skin elasticity loss, we measured the expression of matrix metalloproteinase (MMP)-2, -9, and -13. AVGP prevented both the UVB-induced increases in MMPs expressions. Moreover, we investigated hyaluronic acid (HA) content of mice dorsal skin and gene expression of HA synthase-2 (Has2). In the results, AVGP oral administration prevented UVB-induced decreasing in skin HA content and Has2 expression and attenuates the UVB-induced decrease in serum adiponectin, which promotes Has2 expression. These results suggested that AVGP has the ability to prevent the skin photoaging. AVGP has the potent anti-photoaging activity via suppressing UVB-induced overexpression of MMPs and loss of hyaluronic acid. |
| Databáze: | OpenAIRE |
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