Pelvic MRI findings in relapsed prostate cancer after radical prostatectomy
| Autor: | Hernández, Diana, Salas, D., Giménez, D., Buitrago, P., Esquena, Salvador, Palou, Juan, de la Torre, P., Pernas, J., Gich, Ignasi, Gómez de Segura, G., Craven-Bartle, Jordi, Sancho, G., Universitat Autònoma de Barcelona |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Multivariate analysis medicine.medical_treatment Malignancy Pelvis Prostate cancer Image Interpretation Computer-Assisted Humans Medicine Radiology Nuclear Medicine and imaging Lymph node Aged Retrospective Studies Aged 80 and over Prostatectomy Salvage Therapy Radiotherapy business.industry Multiparametric MRI Research Prostatic Neoplasms Middle Aged medicine.disease Magnetic Resonance Imaging Radical prostatectomy Surgery Radiation therapy Salvage radiotherapy Lymphatic system medicine.anatomical_structure Oncology Radiology Nuclear Medicine and imaging Lymphatic Metastasis Biochemical failure Lymph Radiology Neoplasm Recurrence Local business |
| Zdroj: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Radiation Oncology r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau Instituto de Salud Carlos III (ISCIII) Radiation Oncology (London, England) |
| ISSN: | 1748-717X |
| Popis: | Purpose/Objective: Little is known about the clinical impact of using multiparametric MRI to plan early salvage radiotherapy after radical prostatectomy. We aimed to evaluate the incidence and location of recurrence based on pelvic multiparametric MRI findings and to identify clinical variables predictive of positive imaging results. Materials and methods: We defined radiological criteria of local and lymph node malignancy and reviewed records and MRI studies of 70 patients with PSA recurrence after radical prostatectomy. We performed univariate and multivariate analysis to identify any association between clinical, pathological and treatment-related variables and imaging results. Results: Multiparametric MRI was positive in 33/70 patients. We found local and lymph node recurrence in 27 patients and 7 patients, respectively, with a median PSA value of 0.38 ng/ml. We found no statistically significant differences between patients with positive and negative multiparametric MRI for any variable. Shorter PSADT was associated with positive lymph nodes (median PSADT: 5.12 vs 12.70 months; p: 0.017). Conclusions: Nearly half the patients had visible disease in multiparametric MRI despite low PSA. Positive lymph nodes incidence should be considered when planning salvage radiotherapy, particularly in patients with a short PSADT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink