Natural evolution in pediatric cutaneous mastocytosis: 10-year follow-up
| Autor: | Anton Żawrocki, Roman Nowicki, Justyna Czarny, Magdalena Lange, Joanna Renke |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Mastocytosis Cutaneous Diffuse cutaneous mastocytosis Spontaneous remission Dermatology Disease 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Myeloproliferative Disorders medicine Humans Mast Cells Child Skin Heterogeneous group Cutaneous Mastocytosis business.industry 10 year follow up Mast cell medicine.anatomical_structure 030220 oncology & carcinogenesis business Mastocytosis Follow-Up Studies |
| Zdroj: | International journal of dermatologyREFERENCES. 60(10) |
| ISSN: | 1365-4632 |
| Popis: | Background Mastocytosis is a heterogeneous group of myeloproliferative disorders characterized by accumulation of clonal mast cells in various tissues. The aim of this study was to determine the symptoms evolution and outcome after 10 years observation. Methods Fifty-five children with mastocytosis were included in the study group and monitored concerning mast cell mediator-related symptoms (MC MRSs) and clinical course of the disease for a period of ≥10 years. Results Patients presented with a maculopapular cutaneous form of mastocytosis (MPCM) (n = 47) and diffuse cutaneous mastocytosis (DCM) (n = 8). The complete remission (CR) of skin lesions occurred in 10.3% of children after 10 years observation; no remission (NR) was observed in 17.9% children. The CR of skin specific MC MRS occurred in 69.2% children with MPCM and in 14.3% with DCM. Conclusion Most children with cutaneous mastocytosis (CM) eventually experience a major or partial regression of skin lesions, although complete regression before puberty is rare. The spontaneous remission of skin specific MC MRS is less frequent in children with DCM. |
| Databáze: | OpenAIRE |
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