Carotid intima-media thickness, carotid wall shear stress and restenosis after femoro-popliteal percutaneous transluminal angioplasty (PTA)
| Autor: | J. Katavic, Beatrice Amann-Vesti, B. van der Loo, Valentin Rousson, Silviana Spring, Renate Koppensteiner, Elisabeth Krieger |
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| Přispěvatelé: | University of Zurich, Koppensteiner, R |
| Rok vydání: | 2005 |
| Předmět: |
Male
Duplex ultrasonography medicine.medical_treatment Blood viscosity Pilot Projects Femoral artery Restenosis Recurrence Carotid intima media thickness Medicine Carotid Stenosis Popliteal Artery Prospective Studies Common carotid artery Carotid wall shear stress Medicine(all) Ultrasonography Doppler Duplex Middle Aged Femoropopliteal segment 2746 Surgery Femoral Artery Cardiology cardiovascular system Regression Analysis Female Radiology Tunica Media Cardiology and Cardiovascular Medicine medicine.medical_specialty Carotid Artery Common Arterial Occlusive Diseases 610 Medicine & health 2705 Cardiology and Cardiovascular Medicine Internal medicine Angioplasty medicine.artery Humans cardiovascular diseases Aged Platelet Count business.industry 10060 Epidemiology Biostatistics and Prevention Institute (EBPI) medicine.disease Popliteal artery Intima-media thickness Surgery Balloon angioplasty Tunica Intima business Angioplasty Balloon Follow-Up Studies |
| DOI: | 10.5167/uzh-19198 |
| Popis: | Objective To determine the relationship between carotid intima-media thickness (IMT), carotid wall shear stress (WSS) and restenosis after femoro-popliteal percutaneous transluminal angioplasty (PTA). Patients and methods Thirty-one subjects (18 men, 13 women, median age 69 years) treated with femoro-popliteal PTA for symptomatic peripheral arterial occlusive disease were enrolled. On admission, IMT, internal diameter and blood velocity of the common carotid artery (CCA) were assessed by high-resolution ultrasonography. Blood viscosity was measured and carotid WSS was calculated. Patients were followed up for 6 months for the occurrence of significant restenosis (>50%) as documented by duplex ultrasonography. Two patients were lost to follow-up. Results Fourteen patients (48%) developed restenosis at 6 months. IMT and WSS were not different in patients without and with restenosis (IMT: 0.90 (0.85–0.97) vs. 0.89 (0.84–0.93) mm, p=0.51; WSS: 14.1 (11.9–19.2) vs. 15.9 (12.8–21.5) dyne/cm2, p=0.48). The hazard ratio of incident restenosis as estimated by Cox regression analysis was 0.04 for IMT (p=0.23; 95% CI 0.0001–8.22) and 1.07 for WSS (p=0.10; 95% CI 0.98–1.17). Conclusions In this pilot study involving a limited number of patients, carotid IMT and carotid WSS are not significantly related to restenosis at 6 months after femoro-popliteal PTA. This might be the result of different underlying pathophysiology for atherosclerosis and restenosis. |
| Databáze: | OpenAIRE |
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