Does the Interaction between Maternal Folate Intake and the Methylenetetrahydrofolate Reductase Polymorphisms Affect the Risk of Cleft Lip with or without Cleft Palate?
| Autor: | Christl Vermeij-Keers, Iris A.L.M. van Rooij, Anne Marie Kuijpers-Jagtman, Marga C. Ocké, Gerhard A. Zielhuis, Jan-Jaap van der Biezen, Leo A. J. Kluijtmans, Sieneke M. Goorhuis-Brouwer, Régine P.M. Steegers-Theunissen |
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| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG, Plastic and Reconstructive Surgery and Hand Surgery, Obstetrics & Gynecology |
| Rok vydání: | 2003 |
| Předmět: |
Male
Homocysteine Epidemiology HOMOCYSTEINE Vascular medicine and diabetes [UMCN 2.2] FOLIC-ACID SUPPLEMENTATION chemistry.chemical_compound Genotype Determinants in Health and Disease [EBP 1] genes Oxidoreductases Acting on CH-NH Group Donors biology THERMOLABILE VARIANT vitamins Cleft Palate MTHFR GENE nutrition Female NEURAL-TUBE DEFECTS abnormalities pregnancy Tissue engineering and reconstructive surgery [UMCN 4.3] medicine.medical_specialty Offspring Cleft Lip ORAL CLEFTS folic acid Interventional oncology [UMCN 1.5] Internal medicine Confidence Intervals medicine Humans Methylenetetrahydrofolate Reductase (NADPH2) Pregnancy Polymorphism Genetic Endocrinology and reproduction [UMCN 5.2] business.industry Haplotype Infant Newborn Effective Hospital Care [EBP 2] Case-control study OROFACIAL CLEFTS Maternal Nutritional Physiological Phenomena Odds ratio medicine.disease digestive system diseases Surgery COMMON MUTATION Endocrinology Genetic defects of metabolism [UMCN 5.1] chemistry Case-Control Studies Methylenetetrahydrofolate reductase biology.protein NO EVIDENCE business |
| Zdroj: | American Journal of Epidemiology, 157(7), 583-591. Oxford University Press American Journal of Epidemiology, 157, 583-91 American Journal of Epidemiology, 157, 7, pp. 583-91 |
| ISSN: | 0002-9262 |
| DOI: | 10.1093/aje/kwg005 |
| Popis: | Item does not contain fulltext Periconceptional folic acid supplementation may reduce the risk of cleft lip with or without cleft palate (CL(P)). Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene reduce availability of 5-methyltetrahydrofolate, the predominant circulating form of folate. To determine the effect of MTHFR C677T and MTHFR A1298C genotypes and haplotypes on CL(P) risk and the interaction with maternal periconceptional dietary folate and folic acid supplement intake, the authors conducted a case-control triad study in the Netherlands (1998-2000) among 179 CL(P) and 204 control families. Infant and parental MTHFR C677T and MTHFR A1298C genotypes and haplotypes were not associated with CL(P) risk in the case-control and transmission disequilibrium test analyses. Mothers carrying the MTHFR 677TT genotype and who either did not use folic acid supplements periconceptionally or had a low dietary folate intake, or both, had an increased risk of delivering a CL(P) child (odds ratio (OR) = 5.9, 95% confidence interval (CI): 1.1, 30.9; OR = 2.8, 95% CI: 0.7, 10.5; OR = 10.0, 95% CI: 1.3, 79.1, respectively). No supplement use, low dietary folate intake, and maternal MTHFR 1298CC genotype increased the risk of CL(P) offspring almost sevenfold (OR = 6.5, 95% CI: 1.4, 30.2). Thus, the detrimental effect of low periconceptional folate intake on the risk of giving birth to a CL(P) child was more pronounced in mothers with the MTHFR 677TT or MTHFR 1298CC genotype. |
| Databáze: | OpenAIRE |
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