A case of hypertrophic herpes simplex virus affecting the eyelid and cornea masquerading as IgG4-related disease
| Autor: | Derek B. Laskar, Roman Shinder, Allison E. Rizzuti, Prachi Dua, Douglas R. Lazzaro |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
genetic structures viruses Disease medicine.disease_cause 03 medical and health sciences 0302 clinical medicine lcsh:Ophthalmology Prednisone Cornea Case report medicine 030212 general & internal medicine Past medical history business.industry Symblepharon medicine.disease Dermatology eye diseases Ophthalmology medicine.anatomical_structure Herpes simplex virus lcsh:RE1-994 030221 ophthalmology & optometry IgG4-related disease Eyelid sense organs business medicine.drug |
| Zdroj: | American Journal of Ophthalmology Case Reports American Journal of Ophthalmology Case Reports, Vol 9, Iss C, Pp 68-71 (2018) |
| ISSN: | 2451-9936 |
| Popis: | Purpose To report a case of hypertrophic herpes simplex virus (HSV) of the eyelid and cornea masquerading as IgG4-related disease. Observations A 37-year old African American female with a past medical history of human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) and a recent history of treated genital herpes, presented with an ulcerative lesion of the left upper and lower eyelids, and severe ocular inflammation with symblepharon. Initially, eyelid biopsy revealed findings consistent with IgG4-related disease, and the patient was treated with high dose oral prednisone. After one week of therapy, there was no improvement in the patient's symptoms, and she subsequently developed a corneal epithelial defect which progressed to chronic ulceration. Repeat biopsy and corneal cultures revealed herpes simplex virus type 2. The patient was treated with high dose acyclovir, and the lid lesion improved. The conjunctival inflammation and corneal epithelial defect resolved but symblepharon restricting her eye movement remained. She also developed corneal vascularization and opacification causing severe vision loss. Conclusions and importance Chronic hypertrophic herpes simplex virus infection is a rare condition reported in patients with HIV. While there have been few reports of hypertrophic HSV affecting the eyelid, this is the first reported case of hypertrophic HSV affecting the eye, resulting in severe vision loss. |
| Databáze: | OpenAIRE |
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