| Autor: |
Sabina, Istratoaie, Bianca, Boroş, Ştefan Cristian, Vesa, Raluca, Maria Pop, Gabriel, Cismaru, Dana, Pop, Mircea, Vasile Milaciu, Lorena, Ciumărnean, Vitalie, Văcăraş, Anca, Dana Buzoianu |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Medicine. 101:e31553 |
| ISSN: |
1536-5964 |
| DOI: |
10.1097/md.0000000000031553 |
| Popis: |
Atrial fibrillation (AF) is associated with oxidative stress and inflammation. Paraoxonase-1 (PON1), circulates in blood bound to high-density lipoproteins and reduces systemic oxidative stress. The aim of this study was to evaluate PON1 serum concentration and PON1 arylesterase activity (AREase) in patients with AF. We studied a group of 67 patients with symptomatic paroxysmal or persistent AF admitted for cardioversion and a control group of 59 patients without AF. Clinical parameters, lipid profile, PON1 concentration and AREase were evaluated. A significant difference in serum PON1 concentration and in AREase was found among the two groups. In a multivariate linear regression model, the presence of AF was associated with low PON1 concentration (P = .022). The body mass index was also independently associated with PON1 values (P .001). Only the high-density lipoproteins-cholesterol level was independently associated with AREase (P = .002). PON1 serum concentrations and AREase were diminished in patients with AF, and the presence of AF was independently associated with low PON1 values. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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