Endothelium Dependent and Independent Relaxation of Aortic Rings from Watanabe Heritable Hyperlipidemic Rabbits after Exposure to a Free Radical Generating System
| Autor: | Carlene A. Hamilton, John L. Reid, E. Jardine, Catherine A. Howie |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Nitroprusside Xanthine Oxidase medicine.medical_specialty Carbachol Free Radicals Endothelium Arteriosclerosis Muscle Relaxation Aorta Thoracic Hyperlipidemias In Vitro Techniques Biochemistry Muscle Smooth Vascular chemistry.chemical_compound Internal medicine medicine Animals Xanthine oxidase Hypoxanthine Free-radical theory of aging Dose-Response Relationship Drug Chemistry Cholesterol General Medicine medicine.disease Muscle relaxation Endocrinology medicine.anatomical_structure Female Endothelium Vascular Rabbits medicine.drug |
| Zdroj: | Free Radical Research. 28:251-257 |
| ISSN: | 1029-2470 1071-5762 |
| DOI: | 10.3109/10715769809069277 |
| Popis: | The effects of the xanthine oxidase/hypoxanthine free radical generating system on endothelium dependent and independent relaxation were compared in aortic rings from New Zealand white rabbits and heterozygous Watanabe heritable hyperlipidemic (WHHL) rabbits with mild atherosclerosis. Studies were carried out in young (3 months) and mature (18 months) animals. Plasma cholesterol levels were significantly higher in both 3 and 18 month WHHL animals. Endothelium independent relaxation to SNP did not differ between groups. However, the attenuation of relaxation to carbachol after xanthine oxidase/hypoxanthine treatment tended to be less in WHHL. This reached significance at 18 but not 3 months. We propose that this could be due to increases in levels of endogenous scavenger enzymes in these WHHL rabbits. |
| Databáze: | OpenAIRE |
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