Assessment of tumor treatment response using active contrast encoding (ACE)-MRI: Comparison with conventional DCE-MRI

Autor: Jin Zhang, Sungheon Kim, Kerryanne V. Winters, Mehran Baboli, Karl Kiser
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Gadolinium DTPA
Muscle Physiology
Muscle Functions
Physiology
Cancer Treatment
Contrast Media
030218 nuclear medicine & medical imaging
Diagnostic Radiology
Scan time
Correlation
Mice
0302 clinical medicine
Medicine and Health Sciences
skin and connective tissue diseases
Mice
Inbred BALB C
Multidisciplinary
medicine.diagnostic_test
Chemistry
Pharmaceutics
Radiology and Imaging
Limits of agreement
Animal Models
Magnetic Resonance Imaging
Bevacizumab
Data Acquisition
Oncology
Experimental Organism Systems
Medicine
Fluorouracil
Anatomy
Research Article
Treatment response
Computer and Information Sciences
Imaging Techniques
Science
Muscle Tissue
Antineoplastic Agents
Mouse Models
Research and Analysis Methods
Sensitivity and Specificity
03 medical and health sciences
Model Organisms
Drug Therapy
Diagnostic Medicine
Cell Line
Tumor
medicine
Animals
Mouse tumor
business.industry
Tumor therapy
Biology and Life Sciences
Magnetic resonance imaging
Neoplasms
Experimental
Mice
Inbred C57BL
Biological Tissue
Tumor progression
Animal Studies
Nuclear medicine
business
Drug Delivery
030217 neurology & neurosurgery
Zdroj: PLoS ONE, Vol 15, Iss 6, p e0234520 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: PurposeTo investigate the validity of contrast kinetic parameter estimates from Active Contrast Encoding (ACE)-MRI against those from conventional Dynamic Contrast-Enhanced (DCE)-MRI for evaluation of tumor treatment response in mouse tumor models.MethodsThe ACE-MRI method that incorporates measurement of T1 and B1 into the enhancement curve washout region, was implemented on a 7T MRI scanner to measure tracer kinetic model parameters of 4T1 and GL261 tumors with treatment using bevacizumab and 5FU. A portion of the same ACE-MRI data was used for conventional DCE-MRI data analysis with a separately measured pre-contrast T1 map. Tracer kinetic model parameters, such as Ktrans (permeability area surface product) and ve (extracellular space volume fraction), estimated from ACE-MRI were compared with those from DCE-MRI, in terms of correlation and Bland-Altman analyses.ResultsA three-fold increase of the median Ktrans by treatment was observed in the flank 4T1 tumors by both ACE-MRI and DCE-MRI. In contrast, the brain tumors did not show a significant change by the treatment in either ACE-MRI or DCE-MRI. Ktrans and ve values of the tumors from ACE-MRI were strongly correlated with those from DCE-MRI methods with correlation coefficients of 0.92 and 0.78, respectively, for the median values of 17 tumors. The Bland-Altman plot analysis showed a mean difference of -0.01 min-1 for Ktrans with the 95% limits of agreement of -0.12 min-1 to 0.09 min-1, and -0.05 with -0.37 to 0.26 for ve.ConclusionThe tracer kinetic model parameters estimated from ACE-MRI and their changes by treatment closely matched those of DCE-MRI, which suggests that ACE-MRI can be used in place of conventional DCE-MRI for tumor progression monitoring and treatment response evaluation with a reduced scan time.
Databáze: OpenAIRE
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