Phylogenomics reveals multiple introductions and early spread of SARS‐CoV‐2 into Peru

Autor: Dennis Carhuaricra, Eduardo Juscamayta-López, Faviola Valdivia, Lenin Maturrano, David Tarazona, Ronnie G. Gavilan, Nancy Rojas
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Medical Virology
CONCYTEC-Institucional
Consejo Nacional de Ciencia Tecnología e Innovación Tecnológica
instacron:CONCYTEC
ISSN: 1096-9071
0146-6615
Popis: Peru has become one of the countries with the highest mortality rates from the current coronavirus disease 2019 (COVID‐19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). To investigate early transmission events and the genomic diversity of SARS‐CoV‐2 isolates circulating in Peru in the early COVID‐19 pandemic, we analyzed 3472 viral genomes, of which 149 were from Peru. Phylogenomic analysis revealed multiple and independent introductions of the virus likely from Europe and Asia and a high diversity of genetic lineages circulating in Peru. In addition, we found evidence for community‐driven transmission of SARS‐CoV‐2 as suggested by clusters of related viruses found in patients living in different regions of Peru.
Highlights This is the first snapshot of the sources of epidemic transmission and genomic diversity of SARS‐CoV‐2 lineages circulating in Peru during the early COVID‐19 pandemic. Phylogenomic analysis revealed multiple and independent introductions of the virus likely from Europe and Asia, and high diversity of genetic lineages circulating in Peru with predominance of the G614G variant (S gene,n= 136/149). We found evidence that early spread of the virus in Lima City was sustained by community transmission.
Databáze: OpenAIRE
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