Suppression of mitomycin C-induced micronuclei in mouse bone marrow cells by post-treatment with vanillin
| Autor: | Toshihiro Ohta, Yasuhiko Shirasu, YūF. Sasaki, T. Inouye, Mie Watanabe, Hisako Imanishi |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Health
Toxicology and Mutagenesis medicine.medical_treatment Mitomycin Intraperitoneal injection Mice Inbred Strains Pharmacology Mitomycins chemistry.chemical_compound Mice In vivo Bone Marrow Genetics medicine Animals Molecular Biology Cell Nucleus Chromosome Aberrations Chemistry Vanillin Mitomycin C medicine.anatomical_structure Benzaldehydes Micronucleus test Mutation Bone marrow Micronucleus Antimutagen |
| Zdroj: | Mutation research. 202(1) |
| ISSN: | 0027-5107 |
| Popis: | Induction of micronuclei by mitomycin C (MMC) in mouse bone marrow cells was suppressed by post-treatment with vanillin, a component of vanilla essence flavour. Vanillin was given orally to mice 7.5 h after intraperitoneal injection of 2 mg/kg MMC. Post-treatment with vanillin at 500 mg/kg caused about 50% decrease in the frequency of micronucleated polychromatic erthyrocytes (MN-PCEs). The effect of vanillin administration on the time-course of formation of MN-PCEs was also investigated. The suppressing effect was not due to a delay in the formation of MN-PCEs by the cytotoxic action of vanillin. Vanillin acts as an anticlastogenic factor in vivo. |
| Databáze: | OpenAIRE |
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