Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients

Autor: Giovanna Elisiana Carpagnano, Peter J. Barnes, Sergei A. Kharitonov, E. Gramiccioni, Onofrio Resta, Maria P. Foschino-Barbaro
Rok vydání: 2002
Předmět:
Pulmonary and Respiratory Medicine
Adult
Male
medicine.medical_specialty
Polysomnography
Isoprostanes
Critical Care and Intensive Care Medicine
Gastroenterology
Sensitivity and Specificity
Severity of Illness Index
Statistics
Nonparametric
Reference Values
Internal medicine
Severity of illness
Medicine
Humans
Exhaled breath condensate
Obesity
Prospective Studies
Prospective cohort study
Probability
Sleep Apnea
Obstructive
medicine.diagnostic_test
business.industry
Interleukin-6
Case-control study
Sleep apnea
Interleukin
Middle Aged
medicine.disease
Prognosis
respiratory tract diseases
Respiratory Function Tests
Obstructive sleep apnea
Oxidative Stress
Endocrinology
Breath Tests
Case-Control Studies
Female
Blood Gas Analysis
Inflammation Mediators
Cardiology and Cardiovascular Medicine
business
Biomarkers
Zdroj: Chest. 122(4)
ISSN: 0012-3692
Popis: Obstructive sleep apnea (OSA) is characterized by repeated episodes of upper airways obstruction during sleep that result in episodes of hypoxia. An increase of systemic biomarkers of inflammation and oxidative stress has been found in patients with OSA and obesity.The aim of this study was to measure the levels of markers of inflammation (interleukin [IL]-6) and oxidative stress (8-isoprostane) in the exhaled breath condensate of OSA and obese patients.Eighteen OSA patients (13 men; mean [+/- SEM] age, 44 +/- 7 years), 10 obese subjects (4 men; mean age, 39 +/- 8 years), and 15 healthy age-matched subjects (8 men; mean age, 42 +/- 4 years) were recruited. IL-6 and 8-isoprostane were measured in exhaled breath condensate by a specific enzyme immunoassay kit.Higher concentrations of IL-6 were found in OSA patients (8.7 +/- 0.3 pg/mL) than in healthy control subjects (1.6 +/- 0.1 pg/mL; p0.0001). Obese subjects also had higher levels than healthy control subjects, but lower levels than OSA patients (2.1 +/- 0.2 pg/mL, p0.05 and p0.0001 respectively). Furthermore, 8-isoprostane levels were found to be higher in OSA patients (7.4 +/- 0.7 pg/mL) than in obese subjects (5 +/- 0.3 pg/mL; p = 0.4) and healthy subjects (4.5 +/- 0.5 pg/mL; p0.005). We found a positive correlation between these two markers and neck circumference and apnea/hypopnea index.These findings suggest that inflammation and oxidative stress are characteristic in the airways of OSA patients but not in obese subjects, and that their levels depend on the severity of the OSA. The measurement of IL-6 and 8-isoprostane levels may prove to be useful in screening and monitoring obese patients who have a high risk of developing OSA.
Databáze: OpenAIRE
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