Eprinomectin in dairy zebu Gobra cattle (Bos indicus): plasma kinetics and excretion in milk
| Autor: | Michel Alvinerie, T. Bengone-Ndong, Y. Kane, M. A. Ba, Jean-François Sutra, I. Sane |
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| Přispěvatelé: | Ecole Inter-États des Sciences et Médecine Vétérinaires de Dakar (EISMV), Institut Sénégalais de Recherches Agricoles [Dakar] (ISRA), Unité de recherche Pharmacologie-Toxicologie (UPT), Institut National de la Recherche Agronomique (INRA) |
| Rok vydání: | 2005 |
| Předmět: |
Veterinary medicine
040301 veterinary sciences Administration Topical Biological Availability Bovidae Eprinomectin 030308 mycology & parasitology 0403 veterinary science Excretion 03 medical and health sciences Animal science Ivermectin Pharmacokinetics Blood plasma medicine Animals Dairy cattle 2. Zero hunger Anthelmintics 0303 health sciences General Veterinary biology 04 agricultural and veterinary sciences General Medicine biology.organism_classification Zebu Infectious Diseases [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Milk Insect Science Area Under Curve Parasitology Cattle medicine.drug |
| Zdroj: | Parasitology Research Parasitology Research, Springer Verlag (Germany), 2006, 98 (6), pp.501-506. ⟨10.1007/s00436-005-0103-x⟩ |
| ISSN: | 0932-0113 1432-1955 |
| DOI: | 10.1007/s00436-005-0103-x⟩ |
| Popis: | The pharmacokinetics and mammary excretion of eprinomectin were determined in zebu Gobra following topical administration of 0.5 mg kg(-1). The kinetics of plasma and milk was analysed using a one-compartment model. The maximum plasma concentration of 8.83+/-2.15 ng ml(-1) occurred 1.30 days post-administration. The area under the plasma concentration-time curve was 30.63+/-5.56 ng day(-1) ml(-1) and the mean residence time was 3.38+/-0.60 days. Eprinomectin was detected in milk at the first sampling time and thereafter for at least 8 days. The systemic availability of eprinomectin was significantly lower than that for other breeds of cattle. Comparison of the milk and plasma data demonstrated the parallel disposition of the drug in the milk and plasma with a milk/plasma ratio of 0.094. The very low extent of mammary excretion supports the permitted use of eprinomectin in lactating zebu Gobra. |
| Databáze: | OpenAIRE |
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