COVID-19 in multiple sclerosis and neuromyelitis optica spectrum disorder patients in Latin America

Autor: Liliana Patrucco, Anibal Chertcoff, Deyanira A. Ramirez Navarro, Edgardo Cristiano, Ricardo Alonso, Fatima Pagani Cassara, Juan Ignacio Rojas, Biany Santos Pujols, María C. Ysrraelit, Fernando Hamuy Diaz de Bedoya, Debora Nadur, Lorna Galleguillos Goiry, Verónica Tkachuk, Jimena Miguez, Sebastián Nuñez, Judith Steinberg, Luis C. Rodriguez Salinas, Nicia E. Ramírez Sánchez, Marcos Burgos, Carlos Vrech, Raúl Piedrabuena, Laura Negrotto, Jefferson Becker, Liesbet M. Peeters, Vladimiro Sinay, Aron Benzadon Cohen, Patricio E. Correa Diaz, Orlando Garcea, Pablo A. López, María Laura Menichini, Fernando Gracia, Adriana Tarulla, Luciana Lazaro, Dario Tavolini, Carolina Mainella, Marina Alonso Serena, Adriana Carrá, Berenice Silva, Claudia Cárcamo Rodríguez, Luis A. Garcia Valle, Priscilla Monterrey Alvarez, Geraldine Luetic, Rosalba A. León, Ana M. Toral Granda, Clare Walton, Agustín Pappolla, Geraldine Orozco Escobar, María Eugenia Balbuena, Giordani Rodrigues dos Passos, Roberto Weiser, René Carvajal, Omaira Molina, Norma Deri, Magdalena Casas
Rok vydání: 2021
Předmět:
Zdroj: Multiple Sclerosis and Related Disorders
ISSN: 2211-0348
DOI: 10.1016/j.msard.2021.102886
Popis: BACKGROUND: There is no data regarding COVID-19 in Multiple Sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) patients in Latin America. OBJECTIVE: The objective of this study was to describe the clinical characteristics and outcomes of patients included in RELACOEM, a LATAM registry of MS and NMOSD patients infected with COVID-19. METHODS: RELACOEM is a longitudinal, strictly observational registry of MS and NMOSD patients who suffer COVID-19 and Dengue in LATAM. Inclusion criteria to the registry were either: (1) a biologically confirmed COVID-19 diagnosis based on a positive result of a COVID-19 polymerase chain reaction (PCR) test on a nasopharyngeal swab; or (2) COVID-19-typical symptoms (triad of cough, fever, and asthenia) in an epidemic zone of COVID-19. Descriptive statistics were performed on demographic and clinical variables. The cohort was later stratified for MS and NMOSD and univariate and multivariate logistic regression analysis was performed to identify variables associated with hospitalizations/intensive critical units (ICU) admission. RESULTS: 145 patients were included in the registry from 15 countries and 51 treating physicians. A total of 129 (89%) were MS patients and 16 (11%) NMOSD. 81.4% patients had confirmed COVID-19 and 18.6% were suspected cases. 23 (15.8%) patients were hospitalized, 9 (6.2%) required ICU and 5 (3.4 %) died due to COVID-19. In MS patients, greater age (OR 1.17, 95% CI 1.05 - 1.25) and disease duration (OR 1.39, 95%CI 1.14-1.69) were associated with hospitalization/ICU. In NMOSD patients, a greater age (54.3 vs. 36 years, p=
Databáze: OpenAIRE
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