Ferritin Trajectories over Repeated Whole Blood Donations:Results from the FIND+ Study

Autor: Sara Moazzen, Maike G. Sweegers, Mart Janssen, Boris M. Hogema, Trynke Hoekstra, Katja Van den Hurk
Přispěvatelé: Methodology and Applied Biostatistics, APH - Health Behaviors & Chronic Diseases, APH - Methodology, Internal medicine, Epidemiology and Data Science
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Moazzen, S, Sweegers, M G, Janssen, M, Hogema, B M, Hoekstra, T & van den Hurk, K 2022, ' Ferritin Trajectories over Repeated Whole Blood Donations : Results from the FIND+ Study ', Clinical Chemistry, vol. 11, no. 13, 3581 . https://doi.org/10.3390/jcm11133581
Journal of Clinical Medicine, 11(13):3581, 1-10. MDPI AG
Journal of Clinical Medicine; Volume 11; Issue 13; Pages: 3581
Moazzen, S, Sweegers, M G, Janssen, M, Hogema, B M, Hoekstra, T & Van den Hurk, K 2022, ' Ferritin Trajectories over Repeated Whole Blood Donations : Results from the FIND+ Study ', Journal of Clinical Medicine, vol. 11, no. 13, 3581, pp. 1-10 . https://doi.org/10.3390/jcm11133581
Clinical Chemistry, 11(13):3581
ISSN: 2077-0383
0009-9147
DOI: 10.3390/jcm11133581
Popis: BackgroundWhole blood donors lose approximately 200-250 mg of iron per donation. Depending on post-donation erythropoiesis, available iron stores, and iron absorption rates, optimal donation intervals may differ between donors. This project aims to define subpopulations of donors with different ferritin trajectories over repeated donations.MethodsFerritin levels of 300 new whole blood donors were measured from stored (lookback) samples from each donation over a two-year period in an observational cohort study. Latent classes of ferritin level trajectories were investigated using growth mixture models for male and female donors, separately. Associations of ferritin levels with subsequent iron deficiency and/or low haemoglobin were assessed with generalized linear mixed models.ResultsIn both genders two groups of donors were identified using group-based trajectory modelling. Ferritin levels showed rather linear reductions among 42.9% of male donors and 87.7% of female donors. For the remaining groups of donors, steeper declines in ferritin levels were observed. Ferritin levels at baseline and the end of follow-up varied greatly between groups.ConclusionRepeated ferritin measurements show depleting iron stores in all new whole blood donors, the level at which mainly depends on baseline ferritin levels. Tailored, less intensive donation strategies might help to prevent low iron in donors, and could be supported with ferritin monitoring and/or iron supplementation.
Databáze: OpenAIRE
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