Stereocontrolled addition of Grignard reagents to oxa-bridged benzazepines: highly efficient synthesis of functionalized benzazepine scaffolds

Autor:	Yuewei Zhang, Shuohang Wang, Bao Qingqing, Ning Zhang, Xue Yu
Rok vydání:	2020
Předmět:	Reaction conditions chemistry.chemical_compound Benzazepines 010405 organic chemistry Chemistry General Chemical Engineering Reagent General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Benzazepine
Zdroj:	RSC Advances. 10:41802-41806
ISSN:	2046-2069
Popis:	An efficient and highly diastereoselective synthesis of 2-substituted benzo[b]azepin-5-ol via stereocontrolled addition of Grignard reagents to oxa-bridged benzazepines has been developed. The reaction proceeds efficiently starting from versatile skeletons with mild reaction conditions as well as simple operation. Furthermore, 2-substituted benzazepinones could been obtained by simple Dess–Martin oxidation in excellent yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344b2adf9f95693ec7634254c2d50a39 https://doi.org/10.1039/d0ra08758k Zobrazit plný text záznamu