Endothelial activation and dysfunction in severe fever with thrombocytopenia syndrome
| Autor: | Bo Xing, Ning Cui, Xiao-Ai Zhang, Wei Liu, Hao Li, Qing-Bin Lu, Zhen-Dong Yang, Xiao-Kun Li, Juan Du, Pan-He Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Phlebovirus Physiology Fevers Pathogenesis Pathology and Laboratory Medicine Biochemistry Epithelium chemistry.chemical_compound Blood serum Animal Cells Immune Physiology Medicine and Health Sciences Endothelial dysfunction Innate Immune System lcsh:Public aspects of medicine Hematology Intercellular Adhesion Molecule-1 Vascular endothelial growth factor A medicine.anatomical_structure Infectious Diseases Plasminogen activator inhibitor-1 Cytokines Cellular Types Anatomy Research Article lcsh:Arctic medicine. Tropical medicine Endothelium Adhesion Molecules Infectious Disease Control lcsh:RC955-962 Immunology Biology Bunyaviridae Infections Endothelial activation 03 medical and health sciences Signs and Symptoms Diagnostic Medicine medicine Humans Serum Amyloid A Protein Public Health Environmental and Occupational Health Biology and Life Sciences Endothelial Cells lcsh:RA1-1270 Epithelial Cells Cell Biology Molecular Development medicine.disease Thrombocytopenia Severe fever with thrombocytopenia syndrome 030104 developmental biology Biological Tissue chemistry Immune System Case-Control Studies Plasminogen activator Biomarkers Developmental Biology |
| Zdroj: | PLoS Neglected Tropical Diseases PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005746 (2017) |
| ISSN: | 1935-2735 1935-2727 |
| Popis: | Background Pathogenesis of severe fever with thrombocytopenia syndrome (SFTS) has not been well described yet. Recent studies indicate that SFTSV could replicate in endothelial cells. Here we performed a case-control study to determine whether endothelial activation/dysfunction occurred in SFTSV infection and to identify the biomarkers reflecting endothelial dysfunction. Methodology/Principal findings In a case-control study of 134 SFTS patients and 68 healthy controls, serum levels of plasminogen activator inhibitor 1, tissue plasminogen activator, P-selectin, platelet endothelial cell adhesion molecular, CD40 ligand, E-selectin, vascular endothelial growth factor A, serum amyloid antigen 1 (SAA-1) and vascular cell adhesion molecular 1 were significantly enhanced in the patients than the controls (all P Author summary Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne viral disease and first reported in the rural areas of China. Pathogenesis of the disease has not been well described yet. Recent studies indicated that SFTSV replicated in endothelial cells. So, we performed a case-control study to explore whether endothelial activation/dysfunction occurred in SFTSV infection and to identify biomarkers reflecting endothelial dysfunction. We found that the occurrence of endothelial activation/dysfunction in severe fever with thrombocytopenia syndrome and the serum levels of ICAM-1 and SAA-1 might be used to predict adverse outcome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|