Thyroid hormone effects on the State IV proton motive force in rat liver mitochondria
| Autor: | Mark A. Horrum, Richard B. Tobin, Robert E. Ecklund |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
endocrine system medicine.medical_specialty endocrine system diseases Clinical chemistry Clinical Biochemistry Thyroid Gland Mitochondria Liver Mitochondrion Hyperthyroidism Membrane Potentials Oxygen Consumption Hypothyroidism Internal medicine Respiration medicine Animals Euthyroid Molecular Biology Membrane potential Chemiosmosis Chemistry Thyroid Rats Inbred Strains Cell Biology General Medicine Rats Thyroxine medicine.anatomical_structure Endocrinology Triiodothyronine hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Molecular and Cellular Biochemistry. 103 |
| ISSN: | 1573-4919 0300-8177 |
| DOI: | 10.1007/bf00229588 |
| Popis: | In order to further investigate the mechanisms regulating the control of mitochondrial respiration by thyroid hormone, the proton motive force was measured during State IV respiration in liver mitochondria isolated from euthyroid, hyperthyroid, hypothyroid and T3-treated hypothyroid rats. The proton motive force was significantly higher in the hyperthyroid group due to an increased delta pH. The proton motive force of hypothyroid mitochondria was lower than controls due to a decreased membrane potential. The proton motive force for the T3-treated hypothyroid group did not differ from the euthyroid group due to negating changes in the pH gradient and the membrane potential. The intramitochondrial volume was decreased in the hyperthyroid group and unchanged in the other groups. The results indicate that the thyroid status alters the proton motive force in State IV through individual changes in the pH and membrane potential components of the force. The component that changes in hyperthyroid mitochondria is different from that changing in hypothyroid mitochondria. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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