Clear cell sarcoma arising in the transverse colon
| Autor: | Kyoko Baba, Toshimitsu Suzuki, Toshio Kakihara, Toshifumi Yamaki, Takeaki Fukuda, Tomiko Yamaguchi |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Pathology medicine.medical_specialty Oncogene Proteins Fusion Biology Pathology and Forensic Medicine Fusion gene Melanin Antigens Neoplasm Eosinophilic medicine Humans RNA Neoplasm Aged DNA Primers Melanins Reverse Transcriptase Polymerase Chain Reaction S100 Proteins Transverse colon General Medicine medicine.disease Immunohistochemistry Cytoplasm Colonic Neoplasms Sarcoma Clear Cell Clear-cell sarcoma Sarcoma Transcription Factors |
| Zdroj: | Pathology International. 50:412-416 |
| ISSN: | 1440-1827 1320-5463 |
| DOI: | 10.1046/j.1440-1827.2000.01066.x |
| Popis: | A case of clear cell sarcoma (CCS) arising in the transverse colon is presented. The tumor consisted of sheets or small nests of epithelioid malignant cells possessing pleomorphic nuclei with one or more prominent nucleoli and ample clear or slightly eosinophilic cytoplasm. Some of the tumor cells contained various amounts of melanin pigments that were confirmed by histochemical and ultrastructural examinations. Immunohistochemical examination showed a positive immunoreactivity for HMB45 and S-100 protein. A metastatic nodule, which was found 9 months after surgery, showed similar histological findings to those of the primary one but lacked melanin pigments. Reverse transcriptase- polymerase chain reaction using total ribonucleic acid obtained from metastatic nodule demonstrated the presence of EWS-ATF-1 fusion gene. Based on these findings, the present case tumor is a CCS of the colon. |
| Databáze: | OpenAIRE |
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