Intensive Circulation of Japanese Encephalitis Virus in Peri-urban Sentinel Pigs near Phnom Penh, Cambodia

Autor: Julien Cappelle, Veasna Duong, Véronique Chevalier, Didot Budi Prasetyo, Philippe Dussart, Rithy Choeung, Philippe Buchy, San Sorn, Sivuth Ong, Borin Peng, Lida Kong, Maud Yakovleff, Arnaud Tarantola, Raphaël Duboz, Long Pring
Přispěvatelé: Animal et gestion intégrée des risques (UPR AGIRs), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Unité d'Épidémiologie et de Santé Publique [Phnom Penh], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Unité de Virologie / Virology Unit [Phnom Penh], Royal University of Agriculture, US Naval Medical Research Unit n°2, National Veterinary Research Institute [Phnom Penh], GlaxoSmithKline, Glaxo Smith Kline, This study was undertaken in the framework of the ComAcross project with the financial support of the European Union (EuropeAid, INNOVATE contract 315-047). The study was also supported by the SouthEast Asia Encephalitis project which is funded by Aviesan Sud and Fondation Total. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Rok vydání: 2016
Předmět:
0301 basic medicine
Veterinary medicine
MESH: Swine Diseases
Swine
Epidemiology
Force of infection
Disease Vectors
L73 - Maladies des animaux
Antibodies
Viral
Mosquitoes
Cohort Studies
Geographical Locations
0302 clinical medicine
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Seroepidemiologic Studies
Pig Models
Medicine and Health Sciences
MESH: Animals
Public and Occupational Health
Socioeconomics
MESH: Encephalitis
Japanese
MESH: Swine
MESH: Cohort Studies
Geographic Areas
Encephalitis Virus
Japanese
Swine Diseases
Mammals
biology
Geography
Transmission (medicine)
lcsh:Public aspects of medicine
Agriculture
Animal Models
Vaccination and Immunization
3. Good health
Vaccination
Insects
Culex
Infectious Diseases
Vertebrates
Female
Seasons
Cambodia
Encephalitis
Research Article
Urban Areas
lcsh:Arctic medicine. Tropical medicine
Livestock
Asia
Arthropoda
Infectious Disease Control
lcsh:RC955-962
030231 tropical medicine
Immunology
MESH: Culex
MESH: Insect Vectors
Research and Analysis Methods
03 medical and health sciences
Model Organisms
medicine
Seroprevalence
Animals
Encephalitis
Japanese
MESH: Encephalitis Virus
Japanese
MESH: Seroepidemiologic Studies
Viral encephalitis
MESH: Cambodia
Public Health
Environmental and Occupational Health
Organisms
Biology and Life Sciences
lcsh:RA1-1270
Japanese encephalitis
medicine.disease
biology.organism_classification
Invertebrates
Insect Vectors
030104 developmental biology
Amniotes
People and Places
Earth Sciences
Preventive Medicine
MESH: Female
MESH: Seasons
MESH: Antibodies
Viral
Zdroj: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 10, Iss 12, p e0005149 (2016)
PLoS Neglected Tropical Diseases, Public Library of Science, 2016, 10 (12), pp.e0005149. ⟨10.1371/journal.pntd.0005149⟩
ISSN: 1935-2735
1935-2727
Popis: Despite the increased use of vaccination in several Asian countries, Japanese Encephalitis (JE) remains the most important cause of viral encephalitis in Asia in humans with an estimated 68,000 cases annually. Considered a rural disease occurring mainly in paddy-field dominated landscapes where pigs are amplifying hosts, JE may nevertheless circulate in a wider range of environment given the diversity of its potential hosts and vectors. The main objective of this study was to assess the intensity of JE transmission to pigs in a peri-urban environment in the outskirt of Phnom Penh, Cambodia. We estimated the force of JE infection in two cohorts of 15 sentinel pigs by fitting a generalised linear model on seroprevalence monitoring data observed during two four-month periods in 2014. Our results provide evidence for intensive circulation of JE virus in a periurban area near Phnom Penh, the capital and most populated city of Cambodia. Understanding JE virus transmission in different environments is important for planning JE virus control in the long term and is also an interesting model to study the complexity of vector-borne diseases. Collecting quantitative data such as the force of infection will help calibrate epidemiological model that can be used to better understand complex vector-borne disease epidemiological cycles.
Author Summary Japanese Encephalitis Virus (JEV) is the most important cause of viral encephalitis in Asia in humans with an estimated 68,000 cases annually. The disease is considered a mainly rural one because it occurs mainly in rural areas dominated by paddy fields where the main mosquito species vector of JEV breed. However, other mosquito species, breeding in urban areas, and a large range of animal hosts can play a role in the transmission of JEV, and JEV could therefore be transmitted in peri-urban and urban areas. Our results show an intensive circulation of JEV in sentinel pigs in a peri-urban area of Phnom Penh Cambodia at two different periods of the year. It shows the potential for JEV to circulate in a large range of landscapes and suggest that JEV control should not be limited to rural areas and that JEV may have the potential to emerge and be and be maintained in new areas.
Databáze: OpenAIRE
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