Risk factors for deep vein thrombosis of lower extremities in Sudanese women
| Autor: | Mahmoud Mohamed Elgari, Sanaa Eltahir Abdalla, Fathelrahman M. Hassan, Nadir Ahmed Ibrahim |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Deep vein DNA Mutational Analysis Comorbidity 030204 cardiovascular system & hematology Gene mutation Sudan PCR-RFLP 0302 clinical medicine oral contraceptive Pregnancy Risk Factors Medicine Pharmacology (medical) Original Research Factor V (G1691A) Aged 80 and over Venous Thrombosis 030219 obstetrics & reproductive medicine medicine.diagnostic_test Incidence Age Factors Hematology General Medicine Middle Aged Thrombosis medicine.anatomical_structure Phenotype Lower Extremity Prothrombin G20210A Female Partial Thromboplastin Time Prothrombin Cardiology and Cardiovascular Medicine Partial thromboplastin time Adult medicine.medical_specialty Adolescent Contraceptives Oral Hormonal prothrombin (G20210A) Fibrin Fibrinogen Degradation Products 03 medical and health sciences Young Adult Sex Factors Internal medicine Factor V Leiden Humans Genetic Predisposition to Disease Mobility Limitation Blood Coagulation Aged Prothrombin time business.industry Public Health Environmental and Occupational Health Factor V medicine.disease Peptide Fragments Vascular Health and Risk Management Case-Control Studies Mutation business DVT Biomarkers |
| Zdroj: | Vascular Health and Risk Management |
| ISSN: | 1178-2048 1176-6344 |
| Popis: | Nadir Ahmed Ibrahim,1,2 Fathelrahman M Hassan,3 Mahmoud Mohamed Elgari,2 Sana Eltahir Abdalla4 1Department of Hematology and Immunohematology, College of Medical Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan; 2Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Taibah University, Medina, Saudi Arabia; 3Department of Clinical Laboratory Science, College of Applied Medical Science, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 4Neelain Medical Research Centre, Al Neelain University, Khartoum, Sudan Aim: In this study, we aimed to analyze the genetic and acquired risk factors for deep vein thrombosis (DVT) of the lower extremities among Sudanese women. Methods: A total of 136 women were enrolled in the study, including 75 DVT patients and 61 healthy controls. Demographic and clinical data were collected using a specific questionnaire. Citrated blood samples of patients and controls were used for coagulation assays, and DNAs isolated from EDTA-blood samples were used for the detection of Factor V Leiden and prothrombin G20210A mutations using multiplex polymerase chain reaction-restriction fragment length polymorphism analysis. Results: Both gene mutations were found to be absent from all 136 subjects, and therefore did not account for the incidence of DVT in Sudanese women. Of the 75 DVTs, 70 (93.3%) were localized in the left leg and 5 (6.7%) in the right leg. Additionally, 84% of the DVTs were proximal and 16% were distal. Among the 75 patients, 22 (29.33%) were postpartum, 7 (9.33%) were pregnant, and 46 (61.33%) were nonpregnant. Levels of prothrombin fragment 1+2, prothrombin time, activated partial thromboplastin time, and D-dimer were significantly higher in DVT patients than in healthy controls (P |
| Databáze: | OpenAIRE |
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