ANCA-associated vasculitis and severe proximal muscle weakness
| Autor: | Eugene P. Harper, Erik H. Middlebrooks, Michael Mohseni, Albert Bui, Tochukwu Adaobi Ibe, Goyal Umadat, Jordan S. Dutcher, Michael B. Phillips |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Proximal muscle weakness medicine.diagnostic_test business.industry ANCA-Associated Vasculitis General Medicine medicine.disease Case Studies Magnetic resonance imaging of the brain Autoimmune inflammatory disease Normal creatine medicine Granulomatosis with polyangiitis business Vasculitis Myositis |
| Zdroj: | Proc (Bayl Univ Med Cent) |
| ISSN: | 1525-3252 0899-8280 |
| DOI: | 10.1080/08998280.2020.1871177 |
| Popis: | ANCA-associated vasculitis is a multiorgan autoimmune inflammatory disease that has a heterogeneous clinical presentation. Our case report provides additional evidence supporting the association between granulomatosis with polyangiitis and myositis. In our patient with proximal muscle weakness and pain, a normal creatine kinase and lack of antibodies to muscular fiber units ruled out primary myositis. Distinct magnetic resonance imaging of the brain within the deep gray matter in addition to positive serologies were consistent with a diagnosis of granulomatosis with polyangiitis. ANCA-associated vasculitis, specifically granulomatosis with polyangiitis, may be overlooked if musculoskeletal manifestations are the presenting symptoms. Prompt and aggressive treatment prevented this patient from experiencing multiorgan failure. |
| Databáze: | OpenAIRE |
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