Supramolecular Peptide Assemblies as Antimicrobial Scaffolds
| Autor: | Matthew R. Aronson, Scott H. Medina, Andrew W. Simonson |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pore Forming Cytotoxic Proteins
Prioritization Supramolecular chemistry Pharmaceutical Science Peptide Nanotechnology Review 02 engineering and technology Protein Structure Secondary Analytical Chemistry lcsh:QD241-441 03 medical and health sciences Anti-Infective Agents lcsh:Organic chemistry multidrug resistance Drug Discovery Humans Physical and Theoretical Chemistry 030304 developmental biology chemistry.chemical_classification 0303 health sciences Chemistry Drug discovery Organic Chemistry technology industry and agriculture self-assembly 021001 nanoscience & nanotechnology Antimicrobial Multiple drug resistance Chemistry (miscellaneous) drug delivery Drug delivery Self-healing hydrogels peptides antimicrobial Molecular Medicine 0210 nano-technology |
| Zdroj: | Molecules, Vol 25, Iss 2751, p 2751 (2020) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Antimicrobial discovery in the age of antibiotic resistance has demanded the prioritization of non-conventional therapies that act on new targets or employ novel mechanisms. Among these, supramolecular antimicrobial peptide assemblies have emerged as attractive therapeutic platforms, operating as both the bactericidal agent and delivery vector for combinatorial antibiotics. Leveraging their programmable inter- and intra-molecular interactions, peptides can be engineered to form higher ordered monolithic or co-assembled structures, including nano-fibers, -nets, and -tubes, where their unique bifunctionalities often emerge from the supramolecular state. Further advancements have included the formation of macroscopic hydrogels that act as bioresponsive, bactericidal materials. This systematic review covers recent advances in the development of supramolecular antimicrobial peptide technologies and discusses their potential impact on future drug discovery efforts. |
| Databáze: | OpenAIRE |
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