Hold Your Horses: Impulsivity, Deep Brain Stimulation, and Medication in Parkinsonism
| Autor: | Scott J. Sherman, Michael J. Frank, Johan Samanta, Ahmed A. Moustafa |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Deep brain stimulation Deep Brain Stimulation medicine.medical_treatment Decision Making Dopamine Agents Models Neurological Impulsivity Basal Ganglia Antiparkinson Agents Conflict Psychological Levodopa Subthalamic Nucleus Basal ganglia Reaction Time medicine Humans Learning Aged Dopamine dysregulation syndrome Multidisciplinary business.industry Parkinsonism Cognitive disorder Dopaminergic Parkinson Disease Middle Aged medicine.disease nervous system diseases Subthalamic nucleus Impulsive Behavior Female Neural Networks Computer medicine.symptom business Reinforcement Psychology Neuroscience |
| Zdroj: | Science. 318:1309-1312 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Deep brain stimulation (DBS) of the subthalamic nucleus markedly improves the motor symptoms of Parkinson's disease, but causes cognitive side effects such as impulsivity. We showed that DBS selectively interferes with the normal ability to slow down when faced with decision conflict. While on DBS, patients actually sped up their decisions under high-conflict conditions. This form of impulsivity was not affected by dopaminergic medication status. Instead, medication impaired patients' ability to learn from negative decision outcomes. These findings implicate independent mechanisms leading to impulsivity in treated Parkinson's patients and were predicted by a single neurocomputational model of the basal ganglia. |
| Databáze: | OpenAIRE |
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