Changes in T-cell subpopulations in mice during prolonged experimental secondary infection with Echinococcus granulosus
| Autor: | Antonio Osuna, Dirk Janssen, P. H. De Rycke, M. C. Rueda |
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| Rok vydání: | 1995 |
| Předmět: |
CD4-Positive T-Lymphocytes
Time Factors CD3 Complex Secondary infection T cell CD3 CD4-CD8 Ratio Biophysics Spleen Thymus Gland CD8-Positive T-Lymphocytes Biochemistry Mice Echinococcosis T-Lymphocyte Subsets medicine Splenocyte Animals IL-2 receptor Echinococcus granulosus Molecular Biology Mice Inbred BALB C biology Receptors Interleukin-2 Cell Biology Flow Cytometry biology.organism_classification Molecular biology medicine.anatomical_structure Immunology biology.protein Female CD8 |
| Zdroj: | Bioscience Reports. 15:201-208 |
| ISSN: | 1573-4935 0144-8463 |
| DOI: | 10.1007/bf01540454 |
| Popis: | Balb/c mice were infected intraperitoneally with protoscoleces of Echinococcus granulosus. After 15 months of infection, and by means of flow cytometry, the expression of T-cell markers CD3, CD4, and CDS on T cells from peripheral blood, spleen, and thymus was analyzed and compared with that of age-matched controls. Infected mice had higher percentages of CD3+, and CD4+ cells in peripheral blood, and higher percentages of CD8+ cells in the spleen, when compared with control mice. CD4+ and CD8+ cells in peripheral blood and CD8+ cells in thymus also showed higher percentages of expression of interleukin-2 receptor. The results infer a role for interleukin-2 in experimental secondary echinococcosis. |
| Databáze: | OpenAIRE |
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