Richter Transformation of Chronic Lymphocytic Leukemia: A Review of Fluorodeoxyglucose Positron Emission Tomography–Computed Tomography and Molecular Diagnostics
| Autor: | Frederick Van Gestel, Adeel Ahmad, Faiq Shaikh, Amna Janjua |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Chronic lymphocytic leukemia Malignancy 03 medical and health sciences 0302 clinical medicine pet hemic and lymphatic diseases medicine molecular Positron emission cll Fluorodeoxyglucose Richter transformation business.industry transformation fdg General Engineering medicine.disease Molecular diagnostics Lymphoma 030104 developmental biology Oncology richter 030220 oncology & carcinogenesis Tomography Radiology business medicine.drug |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Chronic lymphocytic leukemia (CLL) is a low-grade B-cell proliferative disease with a generally indolent course. In a few cases, it undergoes transformation and becomes a more aggressive malignancy, such as diffuse large B-cell lymphoma (DLBCL). This process, which is called Richter transformation (RT), is often detected too late and is associated with a poor prognosis. There are multiple molecular diagnostic approaches to detect RT in preexisting CLL. Metabolic imaging using 18-fluorine fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) can be a very useful tool for early detection of RT and which can hence allow for timely intervention, thereby improving the patient's chances of survival. |
| Databáze: | OpenAIRE |
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