Design, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety
| Autor: | Xiudong Ding, Yunlei Hou, Jia Jiang, Yanfang Zhao, Meibo Duan, Yachuang Wu, Baihang Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Staphylococcus aureus
Nitrogen Gram-positive bacteria Clinical Biochemistry Pharmaceutical Science chemistry.chemical_element Microbial Sensitivity Tests Biochemistry chemistry.chemical_compound Structure-Activity Relationship Drug Discovery Drug Resistance Bacterial Moiety Molecular Biology Oxazolidinones biology Drug candidate Organic Chemistry biology.organism_classification Combinatorial chemistry Anti-Bacterial Agents Design synthesis chemistry Mic values Drug Design Linezolid Molecular Medicine Antibacterial activity |
| Zdroj: | Bioorganicmedicinal chemistry letters. 32 |
| ISSN: | 1464-3405 |
| Popis: | A series of novel oxazolidinone derivatives with nitrogen-containing fused heterocyclic moiety were designed and synthesized in this article. Their antibacterial activities were measured against S. aureus, MRSA and MSSA by MIC assay. Most of them exhibited potent activity against Gram-positive pathogens comparable to Linezolid and Radezolid. Compound 3b, which exhibited significant antibacterial activity with MIC values ranging 0.5–1.0 μg/mL, might be a promising drug candidate for further investigation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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