Asymmetric Fluorination of α-Branched Aldehydes by Chiral Primary Amine Catalysis: Reagent-Controlled Enantioselectivity Switch

Autor:	Linfeng Cui, Xueling Mi, Yang'en You, Sanzhong Luo
Rok vydání:	2018
Předmět:	Primary (chemistry) 010405 organic chemistry Chemistry Reagent Organic Chemistry Organic chemistry Amine gas treating Enantiomer 010402 general chemistry 01 natural sciences 0104 chemical sciences Catalysis
Zdroj:	The Journal of Organic Chemistry. 83:4250-4256
ISSN:	1520-6904 0022-3263
Popis:	Asymmetric fluorination of α-branched aldehydes catalyzed by chiral primary amines under mild conditions has been developed. Both enantiomers could be obtained with good yields (up to 96%) and a high enantioselectivity (up to 90% ee) by a simple swap of the fluorination reagents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3444412e1bb65f3ffa124e3def373df4 https://doi.org/10.1021/acs.joc.8b00279 Zobrazit plný text záznamu