Thrombolytic agents: effects of local infusion on microvascular physiology and macrovascular ultrastructure
| Autor: | R D Hogan, A P Evan, Eugene C. Klatte, R W Holden, N U Bang, FE Rabe, G J Becker, P. J. Bendick, R S Dilley, T D Franklin |
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| Rok vydání: | 1983 |
| Předmět: |
Male
Pathology medicine.medical_specialty Endothelium Streptokinase Rodentia Iliac Artery Fibrin Plasminogen Activators Endopeptidases Animals Infusions Intra-Arterial Medicine Thrombolytic Agent Radiology Nuclear Medicine and imaging Platelet activation Urokinase biology business.industry Thrombosis Urokinase-Type Plasminogen Activator Endothelial stem cell medicine.anatomical_structure Cremaster muscle biology.protein business medicine.drug |
| Zdroj: | Radiology. 148:403-406 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.148.2.6346388 |
| Popis: | Microvascular responses in live preparations of rat cremaster muscle were studied with intravital light microscopy following infusions of streptokinase, streptokinase-plasminogen complex, or urokinase into the iliac artery. Structural changes occurring in the endothelium of the iliac arteries were documented by electron microscopy. Though no functional microvascular changes were documented, endothelial cell injury and luminal surface fibrin deposits were identified in the iliac arteries locally infused with the thrombolytic agents. In addition, platelets in various stages of activation were identified. It is concluded that the commonly employed thrombolytic agents, urokinase and streptokinase, caused injury to the endothelial cells of our animal model. It is further concluded that platelet activation, due to local endothelial injury or some other mechanism, occurred following local infusion in our animal model. The long-term effects and potential clinical implications of the findings are not known. |
| Databáze: | OpenAIRE |
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