The Role of Virus-Like Particles in Medical Biotechnology
| Autor: | Sergio Rosales-Mendoza, Mauricio Comas-Garcia, Mayra Colunga-Saucedo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Computer science
viruses Drug Compounding Genetic Vectors Biomedical Technology Pharmaceutical Science 02 engineering and technology Computational biology complex mixtures 030226 pharmacology & pharmacy In vitro diagnostic Virus 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems Drug Discovery Vaccines Virus-Like Particle Biomedicine business.industry virus diseases Genetic Therapy 021001 nanoscience & nanotechnology Molecular Imaging Recombinant vaccines Drug delivery DNA Viral Molecular Medicine RNA Viral 0210 nano-technology business Genetic Engineering Clinical evaluation |
| Zdroj: | Molecular pharmaceutics. 17(12) |
| ISSN: | 1543-8392 |
| Popis: | Virus-like particles (VLPs) are protein-based, nanoscale, self-assembling, cage architectures, which have relevant applications in biomedicine. They can be used for the development of vaccines, imaging approaches, drug and gene therapy delivery systems, and in vitro diagnostic methods. Today, three relevant viruses are targeted using VLP-based recombinant vaccines. VLP-based drug delivery, nanoreactors for therapy, and imaging systems are approaches under development with promising outcomes. Several VLP-based vaccines are under clinical evaluation. Herein, an updated view on the VLP-based biomedical applications is provided; advanced methods for the production, functionalization, and drug loading of VLPs are described, and perspectives for the field are identified. |
| Databáze: | OpenAIRE |
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