The evolving landscape of donor egg treatment: success, women's choice, and anonymity
| Autor: | Alexandra Peyser, Mary Rausch, Nicole Noyes, Stephanie R. Brownridge |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Infertility
Adult Male medicine.medical_specialty Pregnancy Rate Donor egg Reproductive medicine Oocyte Retrieval Fertilization in Vitro Choice Behavior Young Adult Primary outcome Pregnancy Ongoing pregnancy Genetics Medicine Humans Birth Rate Assisted Reproduction Technologies Genetics (clinical) Retrospective Studies Gynecology Cryopreservation Oocyte Donation business.industry Obstetrics and Gynecology Donor oocyte Fertility Preservation General Medicine Middle Aged medicine.disease Embryo Transfer Tissue Donors Treatment success Reproductive Medicine Oocytes Female Psychology business Live birth Confidentiality Demography Anonymity Developmental Biology |
| Zdroj: | J Assist Reprod Genet |
| ISSN: | 1573-7330 |
| Popis: | PURPOSE: To analyze donor oocyte (DE) data across 6 years for oocyte usage efficiency, trends, and whether changes impacted outcomes. METHODS: From 2014 to 2019, 323 DE embryo transfers were completed in 200 recipients using oocytes derived of 163 donors. We assessed data for oocytes being freshly retrieved (FRESH-EGG) vs. purchased frozen (FROZEN-EGG); embryos transferred fresh (FRESH-ET) vs. frozen (FROZEN-ET); cycles SHARED (two recipients) vs. SOLE (one recipient); single (SET) vs. double (DET) embryo transfers and usage of PGT-A. Primary outcome was ongoing pregnancy plus live birth (OP/LB) rate. RESULTS: A total of 229 FRESH-EGG (70%) and 94 FROZEN-EGG (30%) cycles were completed. Overall, the use of FRESH-EGG yielded a higher OP/LB compared to FROZEN-EGG (49% vs. 30%, p = 0.001); within the FRESH-EGG group, OP/LB was similar when comparing FRESH-ET vs. FROZEN-ET (58% vs. 45%, p = 0.07). Within the FRESH-ET group, those using FRESH-EGG had a higher OP/LB than those using FROZEN-EGG (58% vs. 27%, p < 0.001). SHARED vs. SOLE cycles (p = 0.6), donor age (21–32 years; p = 0.4), and age of intended parents (maternal p = 0.3, paternal p = 0.2) did not significantly impact OP/LB. Notably, the use of PGT-A did not improve odds for an OP/LB (p = 0.7). CONCLUSION: The use of FRESH-EGG with FRESH-ET without PGT-A remains superior to newer DE treatment combinations. Specifically, the use of FROZEN-EGG and PGT-A did not improve outcomes. Although changing DE practices may enhance experience and affordability, patients and providers must appreciate that choices do not always favorably impact success. Additionally, newly available genetic-ancestry testing may pose longer-term ramifications mandating change in treatment and/or counseling. |
| Databáze: | OpenAIRE |
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