Incidence rate and characteristics of symptomatic vitamin D deficiency in children: a nationwide survey in Japan
| Autor: | Seiji Fukumoto, Keiichi Ozono, Koji Oba, Haruo Mizuno, Hirokazu Tsukahara, Hirofumi Nakayama, Keisuke Nagasaki, Satoshi Kusuda, Yosikazu Nakamura, Sachiko Kitanaka, Toshimi Michigami, Satomi Koyama, Yukihiro Hasegawa, Ikuma Fujiwara, Kenji Ihara, Noriyuki Takubo, Tohru Yorifuji, Kosei Hasegawa, Taichi Kitaoka, Toshiaki Shimizu, Yuko Sakamoto, Yusuke Tanahashi, Takuo Kubota |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Population Breastfeeding 030209 endocrinology & metabolism Rickets Nationwide survey vitamin D deficiency 03 medical and health sciences 0302 clinical medicine Endocrinology Japan Prevalence medicine Humans 030212 general & internal medicine Vitamin D Child education education.field_of_study Hypocalcemia business.industry Incidence Public health Infant Vitamin D Deficiency medicine.disease Health Surveys Unbalanced diet Confidence interval Child Preschool Female Symptom Assessment business |
| Zdroj: | Endocrine Journal. 65:593-599 |
| ISSN: | 1348-4540 0918-8959 |
| Popis: | There is concern that vitamin D deficiency is prevalent among children in Japan as well as worldwide. We conducted a nationwide epidemiologic survey of symptomatic vitamin D deficiency to observe its incidence rate among Japanese children. A questionnaire inquiring the number of new patients with vitamin D deficiency rickets and/or hypocalcemia for 3 years was sent to 855 randomly selected hospitals with a pediatrics department in Japan. In this survey, we found that 250 children were diagnosed with symptomatic vitamin D deficiency. The estimated number of patients with symptomatic vitamin D deficiency per year was 183 (95% confidence interval (CI): 145-222). The overall annual incidence rate among children under 15 years of age was 1.1 per 100,000 population (95% CI: 0.9-1.4). The second survey has provided detailed information on 89 patients with symptomatic vitamin D deficiency under 5 years of age in hospitals in the current research group. The nationwide and second surveys estimated the overall annual incidence rate of symptomatic vitamin D deficiency in children under 5 years of age to be 3.5 (2.7-4.2) per 100,000 population. The second survey revealed 83% had bowed legs, 88% had exclusive breastfeeding, 49% had a restricted and/or unbalanced diet and 31% had insufficient sun exposure among the 89 patients. This is the first nationwide survey on definitive clinical vitamin D deficiency in children in Japan. Elucidating the frequency and characteristics of symptomatic vitamin D deficiency among children is useful to develop preventative public health strategies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|