Priming does not enhance the efficacy of 1 Hertz repetitive transcranial magnetic stimulation for the treatment of auditory verbal hallucinations: Results of a randomized controlled study

Autor: Jan Dirk Blom, Hans W. Hoek, Iris E. C. Sommer, Christina W. Slotema, Antoin D. de Weijer
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Male
Hallucinations
medicine.medical_treatment
Audiology
Severity of Illness Index
law.invention
Randomized controlled trial
law
Parietal Lobe
SCHIZOPHRENIA
transcranial magnetic stimulation
Single-Blind Method
PLASTICITY
DELUSIONS
Auditory hallucination
Positive and Negative Syndrome Scale
priming TMS
General Neuroscience
musculoskeletal
neural
and ocular physiology
Motor Cortex
LONG-TERM DEPRESSION
auditory verbal hallucination
Middle Aged
FREQUENCY SYNAPTIC ACTIVITY
Treatment Outcome
Schizophrenia
Female
medicine.symptom
Psychology
Priming (psychology)
psychological phenomena and processes
Adult
medicine.medical_specialty
Psychotherapist
Biophysics
RTMS
behavioral disciplines and activities
SHAM-CONTROLLED TRIAL
THRESHOLD
lcsh:RC321-571
Rating scale
Severity of illness
mental disorders
medicine
Humans
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
METAANALYSIS
LEFT TEMPOROPARIETAL CORTEX
medicine.disease
Transcranial magnetic stimulation
nervous system
randomized controlled trial
Neurology (clinical)
Zdroj: Brain Stimulation, Vol 5, Iss 4, Pp 554-559 (2012)
Brain stimulation, 5(4), 554-559. ELSEVIER SCIENCE INC
ISSN: 1935-861X
Popis: BackgroundLow-frequency repetitive transcranial magnetic stimulation (rTMS) applied to the left temporoparietal area (TP) has been investigated as a treatment method for auditory verbal hallucinations (AVH) yielding inconsistent results. In vitro studies have indicated that the effects of low-frequency rTMS can be enhanced by a brief pretreatment phase consisting of high-frequency rTMS (i.e., priming rTMS).ObjectiveThe aim of this single-blind, randomized controlled study was to investigate whether the effects of rTMS on AVH can be enhanced with priming rTMS.MethodsTwenty-three patients with medication-resistant AVH were randomized over two groups: one receiving low-frequency rTMS preceded by 5 minutes of 6 Hertz rTMS; and another receiving low-frequency rTMS without priming. Both treatments were directed at the left TP. The total duration of stimulation was equal in the two groups, namely, 15 sessions of 20 minutes each. The severity of AVH and other psychotic features were measured with the aid of the Auditory Hallucination Rating Scale (AHRS), the Positive and Negative Syndrome Scale (PANSS) and the Psychotic Symptom Rating Scales (PSYRATS).ResultsThe severity of AVH and other psychotic symptoms in the group with priming was not significantly lower after 3 weeks of treatment in comparison to baseline. The group treated with standard rTMS showed a trend toward improvement after 3 weeks of treatment. No significant differences were observed on any of the rating scales between the group with and without priming.ConclusionsThis study does not provide evidence that priming rTMS is an effective treatment for AVH. (C) 2012 Elsevier Inc. All rights reserved.
Databáze: OpenAIRE
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