Protective effects of the lipophilic redox conjugate tocopheryl succinyl-ethyl ferulate on HIV replication
| Autor: | L. Vergnes, Albert Lindenbaum, Catherine Claise, Sophie Barthélémy, Marvin Edeas, Yacine Khalfoun, Serge Labidalle |
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| Jazyk: | angličtina |
| Předmět: |
Coumaric Acids
Phenolic compound medicine.medical_treatment Cell Biophysics HIV Core Protein p24 Biology medicine.disease_cause Virus Replication Biochemistry Monocytes Cell Line Lipophilic drug chemistry.chemical_compound Caffeic Acids Structural Biology Genetics medicine Humans Vitamin E Tocopherol Vitamin A Molecular Biology Cells Cultured chemistry.chemical_classification Reactive oxygen species Human immunodeficiency virus Macrophages organic chemicals virus diseases Cell Biology Glutathione medicine.anatomical_structure chemistry Oxidative stress Lipophilicity HIV-1 bacteria Lipid Peroxidation Conjugate |
| Zdroj: | FEBS Letters. (1-2):15-18 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/S0014-5793(97)01335-5 |
| Popis: | Previously, we demonstrated that ferulate ethyl and tocopherol reduced HIV replication. In this study, we investigate whether the conjugation of both compounds (O-tocopheryl succinyl O-ethyl ferulate) can increase HIV inhibition. We show here for the first time that O-tocopheryl succinyl O-ethyl ferulate inhibits 80% of HIV replication (HIV-1 acute infection and HIV transmission), inhibits cell lipoperoxidation and prevents cellular glutathione consumption. Compared to ferulate ethyl and tocopheryl succinyl, O-tocopheryl succinyl O-ethyl ferulate inhibits more HIV replication. This may be due in part to the great increase in the lipophilicity of this compound. |
| Databáze: | OpenAIRE |
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