Cobalt-Catalyzed Enantioselective Hydroboration of 1,1-Disubstituted Aryl Alkenes

Autor:	Xiaolong Wan, Ziqing Zuo, Lei Zhang, Zheng Huang
Rok vydání:	2014
Předmět:	Aryl Enantioselective synthesis Regioselectivity chemistry.chemical_element General Chemistry Biochemistry Catalysis chemistry.chemical_compound Hydroboration Colloid and Surface Chemistry chemistry Organic chemistry Cobalt
Zdroj:	Journal of the American Chemical Society. 136:15501-15504
ISSN:	1520-5126 0002-7863
Popis:	We report the synthesis of cobalt complexes of novel iminopyridine-oxazoline (IPO) ligands and their application to the asymmetric hydroboration of 1,1-disubstituted aryl alkenes. The new catalysts afforded α-alkyl-β-pinacolatoboranes with exclusive regioselectivity in high yields with up to 99.5% ee. Furthermore, we have applied this method to an efficient synthesis of naproxen.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343ac949a5d7b20f7c42f3e8471c6692 https://doi.org/10.1021/ja5093908 Zobrazit plný text záznamu