The Potential Adjuvanticity of CAvant®SOE for Foot-and-Mouth Disease Vaccine
| Autor: | Eunhee Kim, Jong-Soo Lee, Sung Ho Shin, Hyun Mi Kim, Young-Jung Shim, Sung-Sik Yoo, Jong-Hyeon Park, Hyundong Jo, D. K. Haluwana, Injoong Yoon, W. A. Gayan Chathuranga, Yong Taik Lim, Min Ja Lee, Young-Hoon Ahn, Seong Yun Hwang |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
Immunology Virus CAvant®SOE Immune system adjuvant Antigen vaccine Drug Discovery medicine Pharmacology (medical) Neutralizing antibody Pharmacology biology foot-and-mouth disease virus business.industry Communication Immunogenicity biology.organism_classification Virology water-in-oil emulsion Infectious Diseases Immunization biology.protein Medicine Foot-and-mouth disease virus business Adjuvant |
| Zdroj: | Vaccines Vaccines, Vol 9, Iss 1091, p 1091 (2021) |
| ISSN: | 2076-393X |
| Popis: | Foot-and-mouth disease (FMD) is a notifiable contagious disease of cloven-hoofed mammals. A high potency vaccine that stimulates the host immune response is the foremost strategy used to prevent disease persistence in endemic regions. FMD vaccines comprise inactivated virus antigens whose immunogenicity is potentiated by immunogenic adjuvants. Oil-based adjuvants have clear advantages over traditional adjuvant vaccines; however, there is potential to develop novel adjuvants to increase the potency of FMD vaccines. Thus, we aimed to evaluate the efficacy of a novel water-in-oil emulsion, called CAvant®SOE, as a novel vaccine adjuvant for use with inactivated FMD vaccines. In this study, we found that inactivated A22 Iraq virus plus CAvant®SOE (iA22 Iraq-CAvant®SOE) induced effective antigen-specific humoral (IgG, IgG1, and IgG2a) and cell-mediated immune responses (IFN-γ and IL-4) in mice. Immunization of pigs with a single dose of iA22 Iraq-CAvant®SOE also elicited effective protection, with no detectable clinical symptoms against challenge with heterologous A/SKR/GP/2018 FMDV. Levels of protection are strongly in line with vaccine-induced neutralizing antibody titers. Collectively, these results indicate that CAvant®SOE-adjuvanted vaccine is a promising candidate for control of FMD in pigs. |
| Databáze: | OpenAIRE |
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