fMRI of syntactic processing in typically developing children: Structural correlates in the inferior frontal gyrus
| Autor: | Mirella Dapretto, Ariel Starr, Elizabeth R. Sowell, Susan Y. Bookheimer, Eric Kan, S. Christopher Nuñez, Jennifer Bramen, Tami Katzir |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases Adolescent Brain activity and meditation Cognitive Neuroscience Inferior frontal gyrus Audiology Language Development behavioral disciplines and activities 050105 experimental psychology Lateralization of brain function Article 03 medical and health sciences Typically developing 0302 clinical medicine Child Development medicine Humans 0501 psychology and cognitive sciences Syntax Child language Lateralization fMRI 05 social sciences Neuropsychology nutritional and metabolic diseases Magnetic Resonance Imaging Frontal Lobe Language development Frontal lobe Acoustic Stimulation Multimodal Female Typical development Psychology 030217 neurology & neurosurgery Psychomotor Performance Cognitive psychology |
| Zdroj: | Nuñez, SC; Dapretto, M; Katzir, T; Starr, A; Bramen, J; Kan, E; et al.(2011). fMRI of syntactic processing in typically developing children: Structural correlates in the inferior frontal gyrus. Developmental Cognitive Neuroscience, 1(3), 313-323. doi: 10.1016/j.dcn.2011.02.004. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2v76w92t |
| DOI: | 10.1016/j.dcn.2011.02.004. |
| Popis: | Development of syntactic processing was examined to evaluate maturational processes including left language lateralization functions and increased specialization of brain regions important for syntactic processing. We utilized multimodal methods, including indices of brain activity from fMRI during a syntactic processing task, cortical thickness measurements from structural MRI, and neuropsychological measures. To evaluate hypotheses about increasing lateralization and specialization with development, we examined relationships between cortical thickness and magnitude and spatial activation extent within the left inferior frontal gyrus (IFG) and its right hemisphere homologue. We predicted that increased activation in the left and decreased activation in the right IFG would be associated with increased syntactic proficiency. As predicted, a more mature pattern of increased thickness in the right pars triangularis was associated with decreased activation intensity and extent in the right IFG. These findings suggest a maturational shift towards decreased involvement of the right IFG for syntactic processing. Better syntactic skills were associated with increased activation in the left IFG independent from age, suggesting increased specialization of the left IFG with increased proficiency. Overall, our findings show relationships between structural and functional neurodevelopment that co-occur with improved syntactic processing in critical language regions of the IFG in typically developing children. © 2011 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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