Riparin A, a compound from Aniba riparia, attenuate the inflammatory response by modulation of neutrophil migration
| Autor: | Camila F. Brito, Marcellus H.L.P. Souza, Ronaldo A. Ribeiro, António Teixeira, Celso A. Camara, Renan O. Silva, Stanley Juan Chavez Gutierrez, Irismara S. Silva, André Luiz dos Reis Barbosa, Valdelânia G Silva, Samara R.B. Damasceno, Rivelilson Mendes de Freitas, Geandra B L Nunes, Jand Venes R. Medeiros, José Maria Barbosa Filho |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Thiobarbituric acid Neutrophils medicine.medical_treatment Anti-Inflammatory Agents Inflammation Pharmacology Peritonitis Toxicology medicine.disease_cause Carrageenan Antioxidants Proinflammatory cytokine chemistry.chemical_compound Lauraceae Mice Phenethylamines medicine TBARS Cell Adhesion Animals Edema Leukocyte Rolling Peroxidase Chemistry Extremities General Medicine Oxidative Stress Cytokine Immune System Diseases Immunology Benzamides Cytokines Tumor necrosis factor alpha medicine.symptom Oxidative stress Histamine Leukocyte Disorders |
| Zdroj: | Chemico-biological interactions. 229 |
| ISSN: | 1872-7786 |
| Popis: | Inflammation is a local tissue response to attacks characterized by vascular and cellular events, including intense oxidative stress. Riparin A, a compound obtained from Aniba riparia, has been shown to have antioxidant activity and cytotoxicity in vitro. This study was aimed at evaluating the anti-inflammatory effect of riparin A against acute inflammation. The results of our evaluations in various experimental models indicated that riparin A reduced paw edema induced by carrageenan, compound 48/80, histamine, and serotonin. Furthermore, it decreased leukocyte and neutrophil counts, myeloperoxidase activity, thiobarbituric acid reactive substance (TBARS) levels, and cytokine (tumor necrosis factor-α and interleukin-1β) levels increased by carrageenan-induced peritonitis, and reversed glutathione levels. Riparin A also reduced carrageenan-induced adhesion and rolling of leukocytes on epithelial cells and did not produce gastric-damage as compared with indomethacin. In conclusion, the data show that riparin A reduces inflammatory response by inhibiting vascular and cellular events, modulating neutrophil migration, inhibiting proinflammatory cytokine production, and reducing oxidative stress. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect