Iterative Optimization and Structure–Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity
| Autor: | Han Ju, Lingxin Hou, Fabao Zhao, Ying Zhang, Ruifang Jia, Laura Guizzo, Anna Bonomini, Jiwei Zhang, Zhen Gao, Ruipeng Liang, Chiara Bertagnin, Xiujie Kong, Xiuli Ma, Dongwei Kang, Arianna Loregian, Bing Huang, Xinyong Liu, Peng Zhan |
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| Rok vydání: | 2022 |
| Předmět: |
Drug Resistance
Neuraminidase Antiviral Agents Drug Resistance Viral Enzyme Inhibitors Guanidines Humans Molecular Docking Simulation Oseltamivir Structure-Activity Relationship Influenza A Virus H1N1 Subtype Influenza A Virus H5N1 Subtype Drug Discovery Influenza A Virus Molecular Medicine H1N1 Subtype Viral H5N1 Subtype |
| Zdroj: | Journal of Medicinal Chemistry. 65:11550-11573 |
| ISSN: | 1520-4804 0022-2623 |
| Databáze: | OpenAIRE |
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