Frequencies of Circulating Cytolytic, CD45RA+CD27−, CD8+ T Lymphocytes Depend on Infection with CMV
| Autor: | J. F. L. Weel, Taco W. Kuijpers, Jean-Claude Davin, Mireille T. M. Vossen, Pauline M. E. Wertheim-van Dillen, Mi-Ran Gent, René A. W. van Lier, Paul A. Baars, Marijke T. L. Roos |
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| Přispěvatelé: | Landsteiner Laboratory, Paediatric Infectious Diseases / Rheumatology / Immunology, Paediatric Nephrology, Amsterdam institute for Infection and Immunity, Experimental Immunology |
| Rok vydání: | 2003 |
| Předmět: |
Cytotoxicity
Immunologic Aging Adolescent Immunology Cytomegalovirus Disease Biology Antibodies Viral Lymphocyte Activation Virus Immunophenotyping Interleukin 21 Recurrence T-Lymphocyte Subsets Humans Immunology and Allergy Lymphocyte Count Seroconversion Child Infant virus diseases Acquired immune system Virology Pedigree Tumor Necrosis Factor Receptor Superfamily Member 7 Cytolysis Child Preschool Acute Disease Cytomegalovirus Infections Leukocyte Common Antigens Immunocompetence Cell Division CD8 T-Lymphocytes Cytotoxic |
| Zdroj: | Journal of immunology (Baltimore, Md., 170(8), 4342-4348. American Association of Immunologists |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.170.8.4342 |
| Popis: | Viral infections may cause serious disease unless the adaptive immune system is able to clear the viral agents through its effector arms. Recent identification and functional characterization of subpopulations of human CD8+ T cells has set the stage to study the correlation between the appearance of particular subsets and common viral infections during childhood, i.e., EBV, CMV, varicella-zoster virus (VZV), and the attenuated measles-mumps-rubella (MMR) vaccine strains. In a cohort of 220 healthy children we analyzed lymphocytes and subpopulations of CD4+ and CD8+ T cells. The presence of the cytolytic CD45RA+CD27− subset of CD8+ T cells correlated with prior CMV infection as defined by seroconversion (p < 0.0001). The number of this CD8+ T cell subset remained stable during follow-up over 3 years in 40 children. The CD45RA+CD27− subset of CD8+ T cells first appeared during acute CMV infection and subsequently stabilized at an individual set-point defined by age and immunocompetence. The functional importance of these cells in CMV surveillance was reflected by their increased numbers in immunosuppressed pediatric kidney transplant patients. Preferential expansion of CD8+CD45RA+CD27− cytolytic T cells seems unique for CMV. |
| Databáze: | OpenAIRE |
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