Optimality of poly-vinyl alcohol/starch/glycerol/citric acid in wound dressing applicable composite films
| Autor: | Aritra Das, Chandan Das, Ramagopal Uppaluri, Srirupa Bhattacharyya |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Glycerol
Vinyl alcohol Absorption of water Starch Occlusive Dressings 02 engineering and technology Biochemistry Polyvinyl alcohol Citric Acid 03 medical and health sciences chemistry.chemical_compound Structural Biology Tensile Strength Escherichia coli medicine Response surface methodology Molecular Biology 030304 developmental biology Wound Healing 0303 health sciences General Medicine 021001 nanoscience & nanotechnology Listeria monocytogenes Anti-Bacterial Agents chemistry Polyvinyl Alcohol Swelling medicine.symptom 0210 nano-technology Citric acid Nuclear chemistry |
| Zdroj: | International Journal of Biological Macromolecules. 155:260-272 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2020.03.185 |
| Popis: | This work addresses response surface methodology (RSM) design based investigations to obtain optimality of quaternary formulations [variant macromolecular concentrations of starch (St, 5–10 w/w%), polyvinyl alcohol (PVA, 5–10 w/w%), citric acid (CA, 15–40 wt%) and glycerol (Gl, 15–40 wt%)] associated to wound dressing films. Appropriate combinations of the swelling index (SI), weight loss (WL%) during 27 days, tensile strength (TS) and percentage elongation (%E) have been considered during such studies. The optimized composition was achieved through RSM optimization and exhibited very good water absorption (300.5% SI) and flexibility (87.5%E), and acceptable in-vitro degradation (51.4% WL) and TS (5 MPa) values, which are significantly better than reported data. Further, the film constitution indicated amplified antibacterial effectiveness against both Gram-positive (Listeria monocytogenes) and Gram-negative (Escherichia coli) bacteria and enhanced cell growth (145.5%) to thereby infer upon the potential associated with its application as a viable wound dressing film. |
| Databáze: | OpenAIRE |
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