Patient reported out-come in posttraumatic pituitary deficiency: results from The Danish National Study on Posttraumatic Hypopituitarism
| Autor: | Ulla Feldt-Rasmussen, Louise Lehman Christensen, Peter Laurberg, Jurgita Janukonyte, Jens Sandahl Christiansen, Marianne Andersen, Kirstine Stochholm, Arieh Cohen, Marianne Klose, Aase Wagner |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Denmark Population Hypopituitarism Comorbidity Endocrinology Quality of life Hypogonadotropic hypogonadism Internal medicine medicine Humans Registries education Fatigue education.field_of_study business.industry General Medicine Middle Aged medicine.disease humanities Patient Outcome Assessment Brain Injuries Cohort Quality of Life Patient-reported outcome Female business Cohort study Follow-Up Studies |
| Zdroj: | Klose, M, Krag, K S, Janukonyté, J, Christensen, L L, Cohen, A, Wagner, A, Laurberg, P, Christiansen, J S, Andersen, M & Feldt-Rasmussen, U 2015, ' Patient reported out-come in posttraumatic pituitary deficiency: results from The Danish National Study on Posttraumatic Hypopituitarism ', European Journal of Endocrinology, vol. 172, no. 6, pp. 753-62 . https://doi.org/10.1530/EJE-14-1069 Klose, M, Stochholm, K, Janukonyté, J, Christensen, L L, Cohen, A S, Wagner, A, Laurberg, P, Christiansen, J S, Andersen, M & Feldt-Rasmussen, U 2015, ' Patient reported outcome in posttraumatic pituitary deficiency : results from The Danish National Study on posttraumatic hypopituitarism ', European Journal of Endocrinology, vol. 172, no. 6, pp. 753-762 . https://doi.org/10.1530/EJE-14-1069 Klose, M, Stochholm, K, Janukonyté, J, Christensen, L L, Cohen, A, Wagner, A, Laurberg, P, Christiansen, J S, Andersen, M & Feldt-Rasmussen, U 2015, ' Patient reported out-come in posttraumatic pituitary deficiency : results from The Danish National Study on Posttraumatic Hypopituitarism ', European Journal of Endocrinology, vol. 172, no. 6, pp. 753-762 . https://doi.org/10.1530/EJE-14-1069 |
| DOI: | 10.1530/EJE-14-1069 |
| Popis: | ObjectivePosttraumatic pituitary hormone deficiency is often suggested. The impact of these predominantly mild and often irreproducible deficiencies on outcome is less clear. The aim of the present study was to describe patient reported outcome in a nationala prioriunselected cohort of patients with traumatic brain injury (TBI) in relation to deficiencies identified upon pituitary assessment.Design and methodsWe conducted a nationwide population-based cohort study. Participants were Danish patients with a head trauma diagnosis recorded in the Danish Board of Health diagnostic code registry; 439 patients (and 124 healthy controls) underwent assessment of anterior pituitary function 2.5 years (median) after TBI. Questionnaires on health-related quality of life (QoL) (SF36, EuroQoL-5D, QoL assessment of GH deficiency in adults) and fatigue (MFI-20) were completed in parallel to pituitary assessment.ResultsPatients with TBI had significant detriments in QoL. Impairment (mainly physical scales) related to pituitary deficiency, although only partially confirmed after adjustment for demographic differences. Hypogonadotropic hypogonadism related to several QoL scores. Increasing impairments were observed with declining total testosterone concentrations (men), but not free testosterone concentrations or any other hormone concentrations. Total testosterone was not independently related to impaired QoL and fatigue, after adjustment for demographics, and treatment with antidiabetics, opioids, antidepressants, and anticonvulsants.ConclusionsOnly a very limited relationship between pituitary hormone deficiencies and QoL/fatigue was demonstrated. Due to the dominating influence of concurrent comorbidities, pituitary deficiencies were not independently related to QoL/fatigue. Causality is still to be shown, and whether substitution therapy could be of additional relevance in selected patients needs to be proven. |
| Databáze: | OpenAIRE |
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