HLA-Cw6 homozygosity in plaque psoriasis is associated with streptococcal throat infections and pronounced improvement after tonsillectomy: A prospective case series
| Autor: | Martin I. Sigurdsson, Sigrun L. Sigurdardottir, Ragna Hlin Thorleifsdottir, Helgi Valdimarsson, Jón Ólafsson, Johann E. Gudjonsson, Bardur Sigurgeirsson, Hannes Petersen, Andrew Johnston |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty medicine.medical_treatment Tonsillitis HLA-C Antigens Dermatology Severity of Illness Index Article Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Psoriasis Area and Severity Index Streptococcal Infections Psoriasis Severity of illness medicine Sore throat Humans Prospective Studies Age of Onset Prospective cohort study Alleles Tonsillectomy business.industry Pharyngitis Prognosis medicine.disease Treatment Outcome 030104 developmental biology Female medicine.symptom business Follow-Up Studies |
| Zdroj: | Journal of the American Academy of Dermatology. 75:889-896 |
| ISSN: | 0190-9622 |
| Popis: | Carriage of the HLA-Cw*0602 allele is associated with a particular set of clinical features and treatment responses in psoriasis. Tonsillectomy can improve psoriasis.We sought to evaluate whether HLA-Cw*0602 predicts a favorable outcome after tonsillectomy of patients with psoriasis.This prospective case series followed up 28 tonsillectomized patients with plaque psoriasis for 24 months. The Psoriasis Area and Severity Index, Psoriasis Disability Index, and Psoriasis Life Stress Inventory were used for assessment. Tonsils were swabbed for bacteria and patients genotyped for HLA-Cw*0602.After tonsillectomy, HLA-Cw*0602 homozygotes showed significantly more improvement, compared with heterozygous and HLA-Cw*0602-negative patients. Thus, Psoriasis Area and Severity Index score was reduced by 82% in the homozygous patients compared with 42% and 31%, respectively (P .001), Psoriasis Disability Index score improved by 87% compared with 38% and 41%, respectively (P .001), and Psoriasis Life Stress Inventory score was 82% reduced compared with 60% and 54%, respectively (P .001). The homozygotes more often had psoriasis onset associated with a throat infection (P = .007) and an increased frequency of streptococcal throat infections per lifetime (P = .038).Few patients were included and some data were retrospective.Homozygous HLA-Cw*0602 carriage in plaque psoriasis may predict a favorable outcome after tonsillectomy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect