Protective effect of an adenosine A1 receptor agonist against metamidophos-induced toxicity and brain oxidative stress
| Autor: | Nil Hocaoglu, Yusuf Cem Kaplan, Kubilay Oransay, Sule Kalkan, Nazan Uysal Hazardın, Aylin Akgun, Ayca Topcu, Durgul Ozdemir, Yesim Tuncok, Bekir Ugur Ergur |
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| Rok vydání: | 2009 |
| Předmět: |
Agonist
Male Insecticides Adenosine medicine.drug_class Health Toxicology and Mutagenesis Diaphragm Pharmacology Toxicology medicine.disease_cause Median lethal dose Thiobarbituric Acid Reactive Substances Antioxidants Lethal Dose 50 Adenosine A1 receptor Random Allocation medicine Animals Humans Rats Wistar Dose-Response Relationship Drug Chemistry Brain Organothiophosphorus Compounds Adenosine A1 Receptor Agonists Rats Survival Rate Dose–response relationship Oxidative Stress Biochemistry Toxicity Cholinergic Oxidative stress medicine.drug |
| Zdroj: | Toxicology mechanisms and methods. 19(2) |
| ISSN: | 1537-6524 |
| Popis: | The aim of this study was to evaluate the effects of different doses of an adenosine A(1) selective agonist, phenylisopropyl adenosine (PIA), on metamidophos-induced cholinergic symptoms, mortality, diaphragm muscle necrosis, and brain oxidative stress. A LD50 dose of metamidophos (20 mg/kg body weight, p.o.) was followed by 1 mL/kg body weight of 0.9% NaCl or 1 mg/kg, 2 mg/kg, 3 mg/kg, or 5 mg/kg body weight PIA ip. Incidence of clinical signs including chewing, salivation, convulsion, and respiratory distress did not show any significant difference among all treatment groups (p > 0.05). PIA was found to be effective to reverse the necrotic changes in diaphragm muscle induced by metamidophos significantly in all groups. Brain Thiobarbituric Acid Reactive Substance (TBARS) levels were significantly increased after the metamidophos poisoning. Administration of 2 to 5 mg/kg body weight PIA decreased brain TBARS levels compared to 0.9% NaCl treated rats. The results indicate that, although different doses of PIA reduced the OP-induced oxidative stress and diaphragm necrosis, a single dose of PIA was not able to recover cholinergic signs and symptoms of metamidophos poisoning. |
| Databáze: | OpenAIRE |
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