NEW PREDICTIVE FACTORS OF DIABETIC MACULOPATHY DEVELOPMENT IN DIABETES MELLITUS TYPE 2
| Autor: | O.P. Chernobrivtsev, Yu.O. Panchenko, S.V. Ziablitsev, S.Yu. Mogilevskyy |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
biology Endothelium business.industry diabetes mellitus type 2 diabetic maculopathy endothelin-1 tnfα lcsh:R lcsh:Medicine Diabetic retinopathy Type 2 diabetes medicine.disease Logistic regression biology.organism_classification Gastroenterology medicine.anatomical_structure Enos Diabetes mellitus Internal medicine medicine Endothelial dysfunction business Pathological |
| Zdroj: | Медична наука України, Vol 14, Iss 3-4, Pp 60-65 (2018) |
| ISSN: | 2664-4738 2664-472X |
| DOI: | 10.32345/2664-4738.3-4.2018.08 |
| Popis: | Relevance. In diabetes mellitus (DM), a cascade of pathological reactions unfolds in the vascular endothelium with the formation of endothelial dysfunction (EDF). Its main factors are endothelium hormone – endothelin-1 (ET1), nitric oxide (NO), endothelial NO-synthase (eNOS), and also tumor necrosis factor-α (TNFα). But the unexplored question remains whether EDFs can be used as prognostic markers for the development of diabetic maculopathy. Objective: to find out the prognostic value of EDF factors in the development of diabetic maculopathy (DM) in type 2 diabetes. Material and methods. This study included 152 patients (304 eyes) with type 2 diabetes, which were divided into groups according to the degree of diabetic retinopathy (DR): 1st – initial non-proliferative DR, 2nd – moderate or severe non-proliferative DR and 3rd – proliferative DR. DM was determined by the presence of specific diabetic retinal changes in the macular area according to the International Clinical Gravity Scale of the American Academy of Ophthalmology (2002). The control group consisted of 95 people. The content of ET1, eNOS and TNFα was determined by ELISA; the content of the final NO metabolites (NOx) was determined spectrophotometrically. Statistical data processing was performed using Statistica 10 (StatSoft, Inc., USA). Results. With the progression of DR, there was an increase in the frequency and severity level of DM (p=2.0e-06), which was accompanied by an increase in the blood levels ET1 (3.7-4.7 times), NOx (1.4-1.5 times) and TNFα (4.2-6.5 times), with a progressive decrease in the level of eNOS (P |
| Databáze: | OpenAIRE |
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