Retinal vessel analysis as a novel screening tool to identify childhood acute lymphoblastic leukemia survivors at risk of cardiovascular disease
| Autor: | Sudhashini Chandrasekaran, Tom MacGillivray, Rosli Es, Ling Ling Chua, Mohamad Shafiq Azanan, Hany Ariffin, Lixian Oh, Tong Foh Chin, Tengku Ain Kamalden, Revathi Rajagopal, Norlina Ramli, Reena Rajasuriar, Tsiao Yi Yap, Emanuele Trucco |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Oncology Central retinal artery medicine.medical_specialty Adolescent Childhood leukemia Disease Endothelial activation Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors medicine.artery Internal medicine Humans Mass Screening Medicine Screening tool Survivors Endothelial dysfunction Childhood Acute Lymphoblastic Leukemia Framingham Risk Score business.industry Retinal Vessels Retinal Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma Prognosis medicine.disease Retinal vessel chemistry Cardiovascular Diseases Case-Control Studies 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Arterial stiffness Cardiology Female business Follow-Up Studies 030215 immunology |
| Zdroj: | Yearbook of Paediatric Endocrinology. |
| ISSN: | 1662-4009 |
| DOI: | 10.1530/ey.17.9.11 |
| Popis: | BACKGROUND Microvascular endothelial dysfunction is central to the pathogenesis of cardiovascular disease (CVD). The eye offers direct access for endothelial health assessment via the retinal microvasculature. The aim of the study was to investigate whether image-based retinal vessel analysis is a feasible method of assessing endothelial health in survivors of childhood acute lymphoblastic leukemia (cALL). MATERIALS AND METHODS Cardiovascular risk factors (CRFs) were estimated using the 30-year Framingham Risk Score in 73 childhood leukemia survivors (median age: 25; median years from diagnosis: 19) and 78 healthy controls (median age: 23). Radial arterial stiffness was measured using pulse wave analyzer, while endothelial activation markers were measured by soluble intercellular adhesion molecule 1 (sICAM-1) and soluble vascular cell adhesion molecule 1 (sVCAM-1). Retinal fundus images were analyzed for central retinal artery/vein equivalents (CRAE/CRVE) and arteriolar-venular ratio (AVR). RESULTS cALL survivors had higher CRF (P |
| Databáze: | OpenAIRE |
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